Claudia Ottka, Jenni Puurunen, Elisabeth Müller, Corinna Weber, Ruth Klein, Hannes Lohi
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Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine.
Introduction: Metabolomics studies in canine endocrine abnormalities are sparse and basic information on these abnormalities must be generated.
Objectives: To characterize the metabolic changes associated with elevated fructosamine, reflecting poor glycemic control, and low thyroxine, a thyroid hormone controlling metabolism.
Methods: Leftovers of clinical serum samples; 25 controls, 79 high fructosamine, and 47 low thyroxine, were analyzed using 1H NMR and differences were evaluated using Firth logistic regression.
Results: Both high fructosamine and low thyroxine were associated with changes in concentrations of multiple metabolites, including glycoprotein acetyls and lipids.
Conclusion: These findings suggest promising makers for further research and clinical validation.
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