{"title":"甲状腺功能减退症患者FT3、FT4、TSH与骨吸收指标关系的研究","authors":"Asma'a H Mohamed, Noor S Naji, Ali H Al-Saadi","doi":"10.47750/jptcp.2022.929","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to find the effect of hypothyroidism in men on metabolism and bone mineral density.</p><p><strong>Method: </strong>The study included a patients group of 90 men suffering from hypothyroidism and 120 healthy subjects as a control group. The study comprised the estimation of the concentration of Blood free triiodothyronine (FT3), free thyroid hormone (FT4), thyroid stimulating hormone (TSH), bone resorption index type I collagen C-terminal peptide (CTX-1), the serum calcium (Ca2+), serum phosphorus (Pi3+), the bone mineral density of the lumbar spine and femoral neck.</p><p><strong>Results: </strong>In the hypothyroidism men group: (1) the bone mass was lower than the control group with significant differences, (2) the bone resorption index CTX-1 was significantly higher than that in the control group and calcium and phosphorus were not different from those in healthy control subjects, and (3) TSH was positively correlated with CTX-1. Male TSH and CTX-1 levels were positively correlated.</p><p><strong>Conclusions: </strong>There is bone loss in men with hypothyroidism, which may be related to increased bone resorption.</p>","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"29 2","pages":"e33-e39"},"PeriodicalIF":0.0000,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Study of the relationship between FT3, FT4, and TSH with bone resorption indices in men with hypothyroidism.\",\"authors\":\"Asma'a H Mohamed, Noor S Naji, Ali H Al-Saadi\",\"doi\":\"10.47750/jptcp.2022.929\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>This study aimed to find the effect of hypothyroidism in men on metabolism and bone mineral density.</p><p><strong>Method: </strong>The study included a patients group of 90 men suffering from hypothyroidism and 120 healthy subjects as a control group. The study comprised the estimation of the concentration of Blood free triiodothyronine (FT3), free thyroid hormone (FT4), thyroid stimulating hormone (TSH), bone resorption index type I collagen C-terminal peptide (CTX-1), the serum calcium (Ca2+), serum phosphorus (Pi3+), the bone mineral density of the lumbar spine and femoral neck.</p><p><strong>Results: </strong>In the hypothyroidism men group: (1) the bone mass was lower than the control group with significant differences, (2) the bone resorption index CTX-1 was significantly higher than that in the control group and calcium and phosphorus were not different from those in healthy control subjects, and (3) TSH was positively correlated with CTX-1. Male TSH and CTX-1 levels were positively correlated.</p><p><strong>Conclusions: </strong>There is bone loss in men with hypothyroidism, which may be related to increased bone resorption.</p>\",\"PeriodicalId\":73904,\"journal\":{\"name\":\"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique\",\"volume\":\"29 2\",\"pages\":\"e33-e39\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-06-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47750/jptcp.2022.929\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47750/jptcp.2022.929","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Study of the relationship between FT3, FT4, and TSH with bone resorption indices in men with hypothyroidism.
Aim: This study aimed to find the effect of hypothyroidism in men on metabolism and bone mineral density.
Method: The study included a patients group of 90 men suffering from hypothyroidism and 120 healthy subjects as a control group. The study comprised the estimation of the concentration of Blood free triiodothyronine (FT3), free thyroid hormone (FT4), thyroid stimulating hormone (TSH), bone resorption index type I collagen C-terminal peptide (CTX-1), the serum calcium (Ca2+), serum phosphorus (Pi3+), the bone mineral density of the lumbar spine and femoral neck.
Results: In the hypothyroidism men group: (1) the bone mass was lower than the control group with significant differences, (2) the bone resorption index CTX-1 was significantly higher than that in the control group and calcium and phosphorus were not different from those in healthy control subjects, and (3) TSH was positively correlated with CTX-1. Male TSH and CTX-1 levels were positively correlated.
Conclusions: There is bone loss in men with hypothyroidism, which may be related to increased bone resorption.
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