慢性阻塞性肺病住院患者中亚理想峰值吸气流量的高患病率:一项现实世界研究。

IF 2.3 4区 医学 Q2 RESPIRATORY SYSTEM
Donald A Mahler, Shaban Demirel, Ramon Hollander, Gokul Gopalan, Asif Shaikh, Cathy D Mahle, Jessica Elder, Curtis Morrison
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引用次数: 1

摘要

为了获得最佳的药物输送,干粉吸入器(dpi)依赖于患者的峰值吸气流量(PIF)和设备的内阻来产生湍流能量并分解粉末。不理想的PIF可能导致药物吸入肺部无效。我们的目的是报告在任何原因住院的COPD患者中使用1个或多个dpi的亚理想PIF的患病率。在这项现实世界的、观察性的、单位点的回顾性研究中,使用In- check™DIAL装置测量每个DPI的PIF,以匹配每个患者使用的DPI的阻力。进行通信
本文章由计算机程序翻译,如有差异,请以英文原文为准。

High Prevalence of Suboptimal Peak Inspiratory Flow in Hospitalized Patients With COPD: A Real-world Study.

High Prevalence of Suboptimal Peak Inspiratory Flow in Hospitalized Patients With COPD: A Real-world Study.

For optimal drug delivery, dry powder inhalers (DPIs) depend on the patient's peak inspiratory flow (PIF) and the internal resistance of the device to create turbulent energy and disaggregate the powder. A suboptimal PIF may lead to ineffective drug inhalation into the lungs. Our objective was to report the prevalence of suboptimal PIF in patients with COPD hospitalized for any reason using 1 or more DPIs. In this real-world, observational, single‑site, retrospective study, PIF was measured for each DPI using the In-Check™ DIAL set to match the resistance of the DPI used by each patient. PIFs <60 and <30L/min were considered suboptimal for low to medium-high- and high-resistance DPIs, respectively. At initial hospitalization, the prevalence of suboptimal PIF was 44.6% in 829 patients (mean age, 71.7 years; 56.8% female); 21.2% were measured during admission for a COPD exacerbation. Suboptimal PIF percentages were 61.0% (38.1±9.5L/min [mean±standard deviation (SD)]) across low to medium-high-resistance DPIs and 17.2% (20.7±4.2L/min) for high-resistance DPIs. Overall, 190/829 patients had 1 or more 30-day all-cause readmission with 253 corresponding PIF measurements. For readmissions, suboptimal PIFs were observed in 49.5% (94/190) of patients. Suboptimal PIF percentages were 65.4% (38.4±9.2L/min) for low to medium-high-resistance DPIs and 19.8% (22.4±3.3L/min) for high-resistance DPIs. As the overall prevalence of suboptimal PIFs in hospitalized patients with COPD varied according to the specific internal resistance of the DPI, these findings may have clinical implications for inhaler selection.

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来源期刊
CiteScore
3.70
自引率
8.30%
发文量
45
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