表面的流行,真实的流行。

IF 3.8 3区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Farrokh Habibzadeh, Parham Habibzadeh, Mahboobeh Yadollahie
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引用次数: 10

摘要

血清学试验对进行血清流行病学和流行病学研究很重要。然而,所使用的测试通常是不完善的,并产生假阳性和假阴性结果。这就是为什么血清阳性率(表观患病率)通常不能反映疾病或相关病症的真实患病率。在此,我们讨论了从表观患病率和测试敏感性和特异性得出真实患病率的方法。基于蒙特卡罗算法的计算机模拟也被用于进一步检查测量的测试灵敏度和特异性也不确定的情况。然后我们用一个真实的例子来完成我们的回顾。在医学文献中发表的许多流行病学研究中观察到的表观患病率是一个有偏差的估计,除非我们纠正其值,否则无法正确解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The apparent prevalence, the true prevalence.

The apparent prevalence, the true prevalence.

The apparent prevalence, the true prevalence.

The apparent prevalence, the true prevalence.

Serologic tests are important for conducting seroepidemiologic and prevalence studies. However, the tests used are typically imperfect and produce false-positive and false-negative results. This is why the seropositive rate (apparent prevalence) does not typically reflect the true prevalence of the disease or condition of interest. Herein, we discuss the way the true prevalence could be derived from the apparent prevalence and test sensitivity and specificity. A computer simulation based on the Monte-Carlo algorithm was also used to further examine a situation where the measured test sensitivity and specificity are also uncertain. We then complete our review with a real example. The apparent prevalence observed in many prevalence studies published in medical literature is a biased estimation and cannot be interpreted correctly unless we correct the value.

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来源期刊
Biochemia Medica
Biochemia Medica 医学-医学实验技术
CiteScore
5.50
自引率
3.00%
发文量
70
审稿时长
>12 weeks
期刊介绍: Biochemia Medica is the official peer-reviewed journal of the Croatian Society of Medical Biochemistry and Laboratory Medicine. Journal provides a wide coverage of research in all aspects of clinical chemistry and laboratory medicine. Following categories fit into the scope of the Journal: general clinical chemistry, haematology and haemostasis, molecular diagnostics and endocrinology. Development, validation and verification of analytical techniques and methods applicable to clinical chemistry and laboratory medicine are welcome as well as studies dealing with laboratory organization, automation and quality control. Journal publishes on a regular basis educative preanalytical case reports (Preanalytical mysteries), articles dealing with applied biostatistics (Lessons in biostatistics) and research integrity (Research integrity corner).
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