循环环状rna作为诊断原发性高血压伴颈动脉斑块的生物标志物

IF 1.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension Pub Date : 2022-10-03 Epub Date: 2022-07-05 DOI:10.1080/10641963.2022.2093894

Zebo Zhang, Haiyan Qian, Zhenbo Tao, Yanqing Xie, Shuai Zhi, Liufang Sheng, Wenming He, Lina Zhang

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引用次数: 0

摘要

背景:目前，尚无原发性高血压(EH)引起的亚临床靶器官损害(如颈动脉斑块)的早期诊断指标。本研究旨在鉴定颈动脉斑块EH中的环状rna (circRNAs)，并评估其作为生物标志物的效用。方法:首先，通过微基因分析和数据库预测鉴定环状rna。其次，对伴有颈动脉斑块的EH患者(n = 100)和健康对照组(n = 100)进行病例对照研究，以评估外周血中circRNAs的表达。最后，建立受试者工作特征(ROC)曲线，评价其诊断价值。结果:5个circrna (hsa_circ_0105130、hsa_circ_0109569、hsa_circ_0072659、hsa_circ_0079586和hsa_circ_0064684)被鉴定为候选circrna。我们发现病例组的circrna与对照组相比有所增加(P < 0.05)。ROC结果显示，这5种circrna，尤其是hsa_circ_0109569 (AUC = 0.741)均具有中等的预测价值。结论:我们的研究表明，循环环状rna可能作为早期检测和人群筛查eh诱导的亚临床靶器官损伤的有前途的无创生物标志物。

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Circulating circular RNAs as biomarkers for the diagnosis of essential hypertension with carotid plaque.

Background: At present, no early diagnostic markers for essential hypertension (EH)-induced subclinical target organs damage (such as carotid plaque) are available. This study aimed to identify the circular RNAs (circRNAs) in EH with carotid plaques, and assess their utility as biomarkers.

Methods: First, circRNAs were identified through microarry analysis and database prediction. Second, a case-control study of EH patients with carotid plaque (n = 100) and healthy controls (n = 100) was performed to evaluate circRNAs expression in peripheral blood. Finally, receiver operating characteristic (ROC) curve was established to evaluate the diagnostic value.

Results: Five circRNAs (hsa_circ_0105130, hsa_circ_0109569, hsa_circ_0072659, hsa_circ_0079586 and hsa_circ_0064684) were identified as the candidate circRNAs. We found that circRNAs were increased in case group compared with controls (P < .05). The results of ROC shown that these five circRNAs, especially hsa_circ_0109569 (AUC = 0.741), all had the moderate predictive value.

Conclusions: Our study revealed circulating circRNAs may act as promising noninvasive biomarkers for early detection and population screening of EH-induced subclinical target organ injury.

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.