Serap Çuhadar, Hayat Özkanay-Yörük, Mehmet Köseoğlu, Kaan Katırcıoğlu
{"title":"动脉血气分析分析前误差的检测。","authors":"Serap Çuhadar, Hayat Özkanay-Yörük, Mehmet Köseoğlu, Kaan Katırcıoğlu","doi":"10.11613/BM.2022.020708","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Blood gas analysis (BGA) is an essential test used for years to provide vital information in critically ill patients. However, the instability of the blood gases is a problem. We aimed to evaluate time and temperature effects on blood gas stability.</p><p><strong>Materials and methods: </strong>Arterial blood was collected from 20 patients into syringes. Following BGA for baseline, syringes were divided into groups to stand at 4°C and 22°C for 30, 60, 90, 120 minutes. All were tested for pH, partial pressure of carbon dioxide (pCO<sub>2</sub>), partial pressure of oxygen (pO<sub>2</sub>), oxygen saturation (sO<sub>2</sub>), oxyhemoglobin (O<sub>2</sub>Hb), sodium, potassium, glucose, lactate, oxygen tension at 50% hemoglobin saturation (p50), and bicarbonate. A subgroup analysis was performed to detect the effect of air on results during storage. Percentage deviations were calculated and compared against the preset quality specifications for allowable total error.</p><p><strong>Results: </strong>At 4°C, pO<sub>2</sub> was the least stable parameter. At 22°C, pO<sub>2</sub> remained stable for 120 min, pH and glucose for 90 min, lactate and pCO<sub>2</sub> for 60 min. Glucose and lactate were stable when chilled. Air bubbles interfered pO<sub>2</sub> regardless of temperatures, whereas pCO<sub>2</sub> increased significantly at 22°C after 30 min, and pH decreased after 90 min. Bicarbonate, sO<sub>2</sub>, O<sub>2</sub>Hb, sodium, and potassium were the unaffected parameters.</p><p><strong>Conclusions: </strong>Correct BGA results are essential, and arterial sample is precious. Therefore, if immediate analysis cannot be performed, up to one hour, syringes stored at room temperature will give reliable results when care is taken to minimize air within the blood gas specimen.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":" ","pages":"020708"},"PeriodicalIF":4.3000,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195608/pdf/","citationCount":"2","resultStr":"{\"title\":\"Detection of preanalytical errors in arterial blood gas analysis.\",\"authors\":\"Serap Çuhadar, Hayat Özkanay-Yörük, Mehmet Köseoğlu, Kaan Katırcıoğlu\",\"doi\":\"10.11613/BM.2022.020708\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Blood gas analysis (BGA) is an essential test used for years to provide vital information in critically ill patients. However, the instability of the blood gases is a problem. We aimed to evaluate time and temperature effects on blood gas stability.</p><p><strong>Materials and methods: </strong>Arterial blood was collected from 20 patients into syringes. Following BGA for baseline, syringes were divided into groups to stand at 4°C and 22°C for 30, 60, 90, 120 minutes. All were tested for pH, partial pressure of carbon dioxide (pCO<sub>2</sub>), partial pressure of oxygen (pO<sub>2</sub>), oxygen saturation (sO<sub>2</sub>), oxyhemoglobin (O<sub>2</sub>Hb), sodium, potassium, glucose, lactate, oxygen tension at 50% hemoglobin saturation (p50), and bicarbonate. A subgroup analysis was performed to detect the effect of air on results during storage. Percentage deviations were calculated and compared against the preset quality specifications for allowable total error.</p><p><strong>Results: </strong>At 4°C, pO<sub>2</sub> was the least stable parameter. At 22°C, pO<sub>2</sub> remained stable for 120 min, pH and glucose for 90 min, lactate and pCO<sub>2</sub> for 60 min. Glucose and lactate were stable when chilled. Air bubbles interfered pO<sub>2</sub> regardless of temperatures, whereas pCO<sub>2</sub> increased significantly at 22°C after 30 min, and pH decreased after 90 min. Bicarbonate, sO<sub>2</sub>, O<sub>2</sub>Hb, sodium, and potassium were the unaffected parameters.</p><p><strong>Conclusions: </strong>Correct BGA results are essential, and arterial sample is precious. Therefore, if immediate analysis cannot be performed, up to one hour, syringes stored at room temperature will give reliable results when care is taken to minimize air within the blood gas specimen.</p>\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":\" \",\"pages\":\"020708\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2022-06-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195608/pdf/\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.11613/BM.2022.020708\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.11613/BM.2022.020708","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
Detection of preanalytical errors in arterial blood gas analysis.
Introduction: Blood gas analysis (BGA) is an essential test used for years to provide vital information in critically ill patients. However, the instability of the blood gases is a problem. We aimed to evaluate time and temperature effects on blood gas stability.
Materials and methods: Arterial blood was collected from 20 patients into syringes. Following BGA for baseline, syringes were divided into groups to stand at 4°C and 22°C for 30, 60, 90, 120 minutes. All were tested for pH, partial pressure of carbon dioxide (pCO2), partial pressure of oxygen (pO2), oxygen saturation (sO2), oxyhemoglobin (O2Hb), sodium, potassium, glucose, lactate, oxygen tension at 50% hemoglobin saturation (p50), and bicarbonate. A subgroup analysis was performed to detect the effect of air on results during storage. Percentage deviations were calculated and compared against the preset quality specifications for allowable total error.
Results: At 4°C, pO2 was the least stable parameter. At 22°C, pO2 remained stable for 120 min, pH and glucose for 90 min, lactate and pCO2 for 60 min. Glucose and lactate were stable when chilled. Air bubbles interfered pO2 regardless of temperatures, whereas pCO2 increased significantly at 22°C after 30 min, and pH decreased after 90 min. Bicarbonate, sO2, O2Hb, sodium, and potassium were the unaffected parameters.
Conclusions: Correct BGA results are essential, and arterial sample is precious. Therefore, if immediate analysis cannot be performed, up to one hour, syringes stored at room temperature will give reliable results when care is taken to minimize air within the blood gas specimen.
期刊介绍:
ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric.
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