Minyoung Oh, Jungsu S Oh, Seung Jun Oh, Sang Ju Lee, Jee Hoon Roh, Woo Ram Kim, Ha-Eun Seo, Jae Myeong Kang, Sang Won Seo, Jae-Hong Lee, Duk L Na, Young Noh, Jae Seung Kim
{"title":"[18F]黄海涛，刘海涛。阿尔茨海默病THK-5351 PET与淀粉样蛋白阴性PET的关系。","authors":"Minyoung Oh, Jungsu S Oh, Seung Jun Oh, Sang Ju Lee, Jee Hoon Roh, Woo Ram Kim, Ha-Eun Seo, Jae Myeong Kang, Sang Won Seo, Jae-Hong Lee, Duk L Na, Young Noh, Jae Seung Kim","doi":"10.3988/jcn.2022.18.4.437","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and purpose: </strong>Alzheimer's disease (AD) does not always mean amyloid positivity. [<sup>18</sup>F]THK-5351 has been shown to be able to detect reactive astrogliosis as well as tau accompanied by neurodegenerative changes. We evaluated the [<sup>18</sup>F]THK-5351 retention patterns in positron-emission tomography (PET) and the clinical characteristics of patients clinically diagnosed with AD dementia who had negative amyloid PET findings.</p><p><strong>Methods: </strong>We performed 3.0-T magnetic resonance imaging, [<sup>18</sup>F]THK-5351 PET, and amyloid PET in 164 patients with AD dementia. Amyloid PET was visually scored as positive or negative. [<sup>18</sup>F]THK-5351 PET were visually classified as having an intratemporal or extratemporal spread pattern.</p><p><strong>Results: </strong>The 164 patients included 23 (14.0%) who were amyloid-negative (age 74.9±8.3 years, mean±standard deviation; 9 males, 14 females). Amyloid-negative patients were older, had a higher prevalence of diabetes mellitus, and had better visuospatial and memory functions. The frequency of the apolipoprotein E ε4 allele was higher and the hippocampal volume was smaller in amyloid-positive patients. [<sup>18</sup>F]THK-5351 uptake patterns of the amyloid-negative patients were classified into intratemporal spread (<i>n</i>=10) and extratemporal spread (<i>n</i>=13). Neuropsychological test results did not differ significantly between these two groups. The standardized uptake value ratio of [<sup>18</sup>F]THK-5351 was higher in the extratemporal spread group (2.01±0.26 vs. 1.61±0.15, <i>p</i>=0.001). After 1 year, Mini Mental State Examination (MMSE) scores decreased significantly in the extratemporal spread group (-3.5±3.2, <i>p</i>=0.006) but not in the intratemporal spread group (-0.5±2.8, <i>p</i>=0.916). The diagnosis remained as AD (<i>n</i>=5, 50%) or changed to other diagnoses (<i>n</i>=5, 50%) in the intratemporal group, whereas it remained as AD (<i>n</i>=8, 61.5%) or changed to frontotemporal dementia (<i>n</i>=4, 30.8%) and other diagnoses (<i>n</i>=1, 7.7%) in the extratemporal spread group.</p><p><strong>Conclusions: </strong>Approximately 70% of the patients with amyloid-negative AD showed abnormal [<sup>18</sup>F]THK-5351 retention. MMSE scores deteriorated rapidly in the patients with an extratemporal spread pattern.</p>","PeriodicalId":324902,"journal":{"name":"Journal of Clinical Neurology (Seoul, Korea)","volume":" ","pages":"437-446"},"PeriodicalIF":0.0000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cf/74/jcn-18-437.PMC9262461.pdf","citationCount":"2","resultStr":"{\"title\":\"[<sup>18</sup>F]THK-5351 PET Patterns in Patients With Alzheimer's Disease and Negative Amyloid PET Findings.\",\"authors\":\"Minyoung Oh, Jungsu S Oh, Seung Jun Oh, Sang Ju Lee, Jee Hoon Roh, Woo Ram Kim, Ha-Eun Seo, Jae Myeong Kang, Sang Won Seo, Jae-Hong Lee, Duk L Na, Young Noh, Jae Seung Kim\",\"doi\":\"10.3988/jcn.2022.18.4.437\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and purpose: </strong>Alzheimer's disease (AD) does not always mean amyloid positivity. [<sup>18</sup>F]THK-5351 has been shown to be able to detect reactive astrogliosis as well as tau accompanied by neurodegenerative changes. We evaluated the [<sup>18</sup>F]THK-5351 retention patterns in positron-emission tomography (PET) and the clinical characteristics of patients clinically diagnosed with AD dementia who had negative amyloid PET findings.</p><p><strong>Methods: </strong>We performed 3.0-T magnetic resonance imaging, [<sup>18</sup>F]THK-5351 PET, and amyloid PET in 164 patients with AD dementia. Amyloid PET was visually scored as positive or negative. [<sup>18</sup>F]THK-5351 PET were visually classified as having an intratemporal or extratemporal spread pattern.</p><p><strong>Results: </strong>The 164 patients included 23 (14.0%) who were amyloid-negative (age 74.9±8.3 years, mean±standard deviation; 9 males, 14 females). Amyloid-negative patients were older, had a higher prevalence of diabetes mellitus, and had better visuospatial and memory functions. The frequency of the apolipoprotein E ε4 allele was higher and the hippocampal volume was smaller in amyloid-positive patients. [<sup>18</sup>F]THK-5351 uptake patterns of the amyloid-negative patients were classified into intratemporal spread (<i>n</i>=10) and extratemporal spread (<i>n</i>=13). Neuropsychological test results did not differ significantly between these two groups. The standardized uptake value ratio of [<sup>18</sup>F]THK-5351 was higher in the extratemporal spread group (2.01±0.26 vs. 1.61±0.15, <i>p</i>=0.001). After 1 year, Mini Mental State Examination (MMSE) scores decreased significantly in the extratemporal spread group (-3.5±3.2, <i>p</i>=0.006) but not in the intratemporal spread group (-0.5±2.8, <i>p</i>=0.916). The diagnosis remained as AD (<i>n</i>=5, 50%) or changed to other diagnoses (<i>n</i>=5, 50%) in the intratemporal group, whereas it remained as AD (<i>n</i>=8, 61.5%) or changed to frontotemporal dementia (<i>n</i>=4, 30.8%) and other diagnoses (<i>n</i>=1, 7.7%) in the extratemporal spread group.</p><p><strong>Conclusions: </strong>Approximately 70% of the patients with amyloid-negative AD showed abnormal [<sup>18</sup>F]THK-5351 retention. MMSE scores deteriorated rapidly in the patients with an extratemporal spread pattern.</p>\",\"PeriodicalId\":324902,\"journal\":{\"name\":\"Journal of Clinical Neurology (Seoul, Korea)\",\"volume\":\" \",\"pages\":\"437-446\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cf/74/jcn-18-437.PMC9262461.pdf\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Neurology (Seoul, Korea)\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3988/jcn.2022.18.4.437\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Neurology (Seoul, Korea)","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3988/jcn.2022.18.4.437","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[18F]THK-5351 PET Patterns in Patients With Alzheimer's Disease and Negative Amyloid PET Findings.
Background and purpose: Alzheimer's disease (AD) does not always mean amyloid positivity. [18F]THK-5351 has been shown to be able to detect reactive astrogliosis as well as tau accompanied by neurodegenerative changes. We evaluated the [18F]THK-5351 retention patterns in positron-emission tomography (PET) and the clinical characteristics of patients clinically diagnosed with AD dementia who had negative amyloid PET findings.
Methods: We performed 3.0-T magnetic resonance imaging, [18F]THK-5351 PET, and amyloid PET in 164 patients with AD dementia. Amyloid PET was visually scored as positive or negative. [18F]THK-5351 PET were visually classified as having an intratemporal or extratemporal spread pattern.
Results: The 164 patients included 23 (14.0%) who were amyloid-negative (age 74.9±8.3 years, mean±standard deviation; 9 males, 14 females). Amyloid-negative patients were older, had a higher prevalence of diabetes mellitus, and had better visuospatial and memory functions. The frequency of the apolipoprotein E ε4 allele was higher and the hippocampal volume was smaller in amyloid-positive patients. [18F]THK-5351 uptake patterns of the amyloid-negative patients were classified into intratemporal spread (n=10) and extratemporal spread (n=13). Neuropsychological test results did not differ significantly between these two groups. The standardized uptake value ratio of [18F]THK-5351 was higher in the extratemporal spread group (2.01±0.26 vs. 1.61±0.15, p=0.001). After 1 year, Mini Mental State Examination (MMSE) scores decreased significantly in the extratemporal spread group (-3.5±3.2, p=0.006) but not in the intratemporal spread group (-0.5±2.8, p=0.916). The diagnosis remained as AD (n=5, 50%) or changed to other diagnoses (n=5, 50%) in the intratemporal group, whereas it remained as AD (n=8, 61.5%) or changed to frontotemporal dementia (n=4, 30.8%) and other diagnoses (n=1, 7.7%) in the extratemporal spread group.
Conclusions: Approximately 70% of the patients with amyloid-negative AD showed abnormal [18F]THK-5351 retention. MMSE scores deteriorated rapidly in the patients with an extratemporal spread pattern.
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