{"title":"XRCC3 18067 C>T (Thr241Met)多态性与宫颈癌和卵巢癌风险的关联:一项系统综述和荟萃分析","authors":"Mojgan Karimi-Zarchi, Mansour Moghimi, Hajar Abbasi, Amaneh Hadadan, Razieh-Sadat Tabatabaei, Atiyeh Javaheri, Hossein Neamatzadeh","doi":"10.1556/1646.11.2019.21","DOIUrl":null,"url":null,"abstract":"<p><p>The 18067 C>T polymorphism of <i>XRCC3</i> gene has been considered to be implicated in the development of cervical and ovarian cancers, but the results are inconsistent. Thus, we conducted a meta-analysis to assess the association of XRCC3 18067 C>T polymorphism with risk of cervical and ovarian cancers. All studies on the association of XRCC3 18067 C>T polymorphism with cervical and ovarian cancers risk were retrieved. Finally, a total of 17 studies including 10 studies with 5,637 cases and 10,057 controls on ovarian cancer and 7 studies with 1,112 cases and 1,233 controls on cervical cancer were selected. Overall, pooled results showed that the XRCC3 18067 C>T polymorphism was significantly associated with increased risk of ovarian cancer (TC vs. CC: OR = 0.904, 95% CI = 0.841-0.972, <i>p</i> = 0.006; TT + TC vs. CC: OR = 0.914, 95% CI = 0.853-0.979, <i>p</i> = 0.010) and cervical cancer (TC vs. CC: OR = 1.00, 95% CI = 1.066-1.585, <i>p</i> = 0.009). Further subgroup analysis by ethnicity revealed an increased risk of cervical and ovarian cancer in Asians and Caucasians, respectively. The present meta-analysis inconsistent with the previous meta-analysis suggests that the XRCC3 18067 C>T polymorphism might be implicated in the pathogenesis of cervical and ovarian cancers.</p>","PeriodicalId":45181,"journal":{"name":"Interventional Medicine and Applied Science","volume":"11 3","pages":"172-181"},"PeriodicalIF":0.0000,"publicationDate":"2019-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/db/imas-11-172.PMC9467339.pdf","citationCount":"2","resultStr":"{\"title\":\"Association of XRCC3 18067 C>T (Thr241Met) polymorphism with risk of cervical and ovarian cancers: A systematic review and meta-analysis.\",\"authors\":\"Mojgan Karimi-Zarchi, Mansour Moghimi, Hajar Abbasi, Amaneh Hadadan, Razieh-Sadat Tabatabaei, Atiyeh Javaheri, Hossein Neamatzadeh\",\"doi\":\"10.1556/1646.11.2019.21\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The 18067 C>T polymorphism of <i>XRCC3</i> gene has been considered to be implicated in the development of cervical and ovarian cancers, but the results are inconsistent. Thus, we conducted a meta-analysis to assess the association of XRCC3 18067 C>T polymorphism with risk of cervical and ovarian cancers. All studies on the association of XRCC3 18067 C>T polymorphism with cervical and ovarian cancers risk were retrieved. Finally, a total of 17 studies including 10 studies with 5,637 cases and 10,057 controls on ovarian cancer and 7 studies with 1,112 cases and 1,233 controls on cervical cancer were selected. Overall, pooled results showed that the XRCC3 18067 C>T polymorphism was significantly associated with increased risk of ovarian cancer (TC vs. CC: OR = 0.904, 95% CI = 0.841-0.972, <i>p</i> = 0.006; TT + TC vs. CC: OR = 0.914, 95% CI = 0.853-0.979, <i>p</i> = 0.010) and cervical cancer (TC vs. CC: OR = 1.00, 95% CI = 1.066-1.585, <i>p</i> = 0.009). Further subgroup analysis by ethnicity revealed an increased risk of cervical and ovarian cancer in Asians and Caucasians, respectively. The present meta-analysis inconsistent with the previous meta-analysis suggests that the XRCC3 18067 C>T polymorphism might be implicated in the pathogenesis of cervical and ovarian cancers.</p>\",\"PeriodicalId\":45181,\"journal\":{\"name\":\"Interventional Medicine and Applied Science\",\"volume\":\"11 3\",\"pages\":\"172-181\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/db/imas-11-172.PMC9467339.pdf\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Interventional Medicine and Applied Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1556/1646.11.2019.21\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/9/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Interventional Medicine and Applied Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1556/1646.11.2019.21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/9/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 2
摘要
XRCC3基因18067 C>T多态性被认为与宫颈癌和卵巢癌的发生有关，但结果并不一致。因此，我们进行了一项荟萃分析，以评估XRCC3 18067 C>T多态性与宫颈癌和卵巢癌风险的关系。检索所有关于XRCC3 18067 C>T多态性与宫颈癌和卵巢癌风险相关性的研究。最后，总共选择了17项研究，包括10项研究，5,637例卵巢癌和10,057例对照，以及7项研究，1,112例宫颈癌和1,233例对照。总体而言，汇总结果显示，XRCC3 18067 C>T多态性与卵巢癌风险增加显著相关(TC vs CC: OR = 0.904, 95% CI = 0.841-0.972, p = 0.006;TT + TC与CC: = 0.914, 95% CI -0.979 = 0.853, p = 0.010)和宫颈癌(TC与CC: = 1.00, 95% CI -1.585 = 1.066, p = 0.009)。进一步的种族亚组分析显示，亚洲人和白种人患宫颈癌和卵巢癌的风险分别增加。本荟萃分析结果与前期荟萃分析结果不一致，提示XRCC3 18067 C>T多态性可能与宫颈癌和卵巢癌的发病机制有关。
Association of XRCC3 18067 C>T (Thr241Met) polymorphism with risk of cervical and ovarian cancers: A systematic review and meta-analysis.
The 18067 C>T polymorphism of XRCC3 gene has been considered to be implicated in the development of cervical and ovarian cancers, but the results are inconsistent. Thus, we conducted a meta-analysis to assess the association of XRCC3 18067 C>T polymorphism with risk of cervical and ovarian cancers. All studies on the association of XRCC3 18067 C>T polymorphism with cervical and ovarian cancers risk were retrieved. Finally, a total of 17 studies including 10 studies with 5,637 cases and 10,057 controls on ovarian cancer and 7 studies with 1,112 cases and 1,233 controls on cervical cancer were selected. Overall, pooled results showed that the XRCC3 18067 C>T polymorphism was significantly associated with increased risk of ovarian cancer (TC vs. CC: OR = 0.904, 95% CI = 0.841-0.972, p = 0.006; TT + TC vs. CC: OR = 0.914, 95% CI = 0.853-0.979, p = 0.010) and cervical cancer (TC vs. CC: OR = 1.00, 95% CI = 1.066-1.585, p = 0.009). Further subgroup analysis by ethnicity revealed an increased risk of cervical and ovarian cancer in Asians and Caucasians, respectively. The present meta-analysis inconsistent with the previous meta-analysis suggests that the XRCC3 18067 C>T polymorphism might be implicated in the pathogenesis of cervical and ovarian cancers.
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