COVID-19后晚期周围性面瘫:快速系统回顾和两例病例报告

IF 1.8 3区 医学 Q4 TOXICOLOGY
Thalitta Mendes Cavalcante, Vanessa Terezinha Gubert, Carolina de Deus Lima, Larissa Anjos Luciano, Mariana Garcia Croda, James Venturini, Antonio Luiz Dal Bello Gasparoto, Wellyngton Matheus Souza Santiago, Ana Rita Coimbra Motta-Castro, Fernanda Paes Reis, Ana Paula da Costa Marques, Aline Pedroso Lorenz, Wellington Santos Fava, Marina Castilhos Souza Umaki Zardin, Cláudia Elizabeth Volpe Chaves, Gabriel Pereira Braga, Anamaria Mello Miranda Paniago, Sandra Maria do Valle Leone de Oliveira
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引用次数: 1

摘要

周围性面瘫(PFP)已被证明是COVID-19的神经系统表现。目前的研究提出了两例COVID-19后PFP病例,并对文献中已知病例进行了快速回顾。两例报告均按照援外合作组织的指导方针进行。我们还于2021年8月30日使用PubMed、Embase和Cochrane Library数据库对与COVID-19暂时相关的PFP病例进行了系统回顾,采用快速回顾方法。两例患者在COVID-19症状出现后102天和110天分别出现PFP。采用逆转录实时聚合酶链反应(RT-qPCR)检测鼻腔样本中SARS-CoV-2 RNA。嗅觉缺失是唯一的神经学表现。两例PFP患者均接受类固醇治疗,随后均完全康复。在快速回顾中,我们确定了764篇文章,纳入了43项研究。其中分析了128例PFP患者,其中42.1%(54/128)为男性,39.06%(50/128)为女性,23例未报告性别。年龄18 ~ 59岁(54.68%);COVID-19和PFP之间的中位时间为3天(从COVID-19首次出现症状到感染急性期后40天)。与COVID-19相关的晚期PFP症状轻微,并随着时间的推移而改善,没有确定的预测因素。晚期PFP应被添加到与SARS-CoV-2感染的长期影响相关的神经学表现谱中,作为COVID-19后病症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Late peripheral facial paralysis after COVID-19: a rapid systematic review and two case reports.

Peripheral facial paralysis (PFP) has been shown to be a neurological manifestation of COVID-19. The current study presents two cases of PFP after COVID-19, along with a rapid review of known cases in the literature. Both case reports were conducted following CARE guidelines. We also performed a systematic review of PFP cases temporally related to COVID-19 using PubMed, Embase, and Cochrane Library databases on August 30, 2021, using a rapid review methodology. The two patients experienced PFP 102 and 110 days after COVID-19 symptom onset. SARS-CoV-2 RNA was detected in nasal samples through reverse-transcription real-time polymerase chain reaction (RT-qPCR) testing. Anosmia was the only other neurological manifestation. PFP was treated with steroids in both cases, with complete subsequent recovery. In the rapid review, we identified 764 articles and included 43 studies. From those, 128 patients with PFP were analyzed, of whom 42.1% (54/128) were male, 39.06% (50/128) female, and in 23 cases the gender was not reported. The age range was 18 to 59 (54.68%). The median time between COVID-19 and PFP was three days (ranging from the first symptom of COVID-19 to 40 days after the acute phase of infection). Late PFP associated with COVID-19 presents mild symptoms and improves with time, with no identified predictors. Late PFP should be added to the spectrum of neurological manifestations associated with the long-term effects of SARS-CoV-2 infection as a post COVID-19 condition.

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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
39
审稿时长
6-12 weeks
期刊介绍: Journal of Venomous Animals and Toxins including Tropical Diseases (JVATiTD) is a non-commercial academic open access publication dedicated to research on all aspects of toxinology, venomous animals and tropical diseases. Its interdisciplinary content includes original scientific articles covering research on toxins derived from animals, plants and microorganisms. Topics of interest include, but are not limited to:systematics and morphology of venomous animals;physiology, biochemistry, pharmacology and immunology of toxins;epidemiology, clinical aspects and treatment of envenoming by different animals, plants and microorganisms;development and evaluation of antivenoms and toxin-derivative products;epidemiology, clinical aspects and treatment of tropical diseases (caused by virus, bacteria, algae, fungi and parasites) including the neglected tropical diseases (NTDs) defined by the World Health Organization.
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