Naomi Niari Dalimunthe, Idrus Alwi, Sally Aman Nasution, Hamzah Shatri
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Total GRACE score was calculated on patient admission and echocardiography was conducted within 72 hours of hospitalization for measurement of MPI. All patients were observed for the incidence of MACE during hospitalization. The incremental predictive value of the GRACE risk score alone and combined with Tei index was assessed by the change in area under the curve (AUC) by DeLong's method, likelihood ratio test (LRT), and continuous net reclassification improvement (cNRI). <b>Results:</b> The addition of Tei index to the GRACE risk score significantly improves the predictive value of the GRACE risk score (increase in AUC from 0.753 for the GRACE risk score to 0.801 for the GRACE score combine with Tei index, p=0.354; LRT=4.65, p=0.030; cNRI=0.515, p=0.046). <b>Conclusions:</b> Adjustment of Tei index to GRACE risk score might improve risk prediction of in-hospital MACE after AMI.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"222-228"},"PeriodicalIF":16.4000,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"The role of Tei index added to the GRACE risk score for prediction of in-hospital MACE after acute myocardial infarction.\",\"authors\":\"Naomi Niari Dalimunthe, Idrus Alwi, Sally Aman Nasution, Hamzah Shatri\",\"doi\":\"10.2478/rjim-2022-0012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Introduction:</b> The Global Registry of Acute Coronary Events (GRACE) risk score is widely recommended for risk assessment in patients with acute myocardial infarction (AMI). 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引用次数: 1
摘要
全球急性冠状动脉事件登记(GRACE)风险评分被广泛推荐用于急性心肌梗死(AMI)患者的风险评估。AMI后可出现不同程度的左室收缩和舒张功能损害。Tei指数是超声心动图参数,代表收缩和舒张期左室表现。既往研究证实Tei指数是AMI后主要不良心血管事件(MACE)的独立预测因子。本研究探讨Tei指数的加入是否可以提高GRACE风险评分的性能,以预测AMI后院内MACE。方法:对75例AMI患者进行前瞻性队列研究。入院时计算GRACE总评分,住院72小时内行超声心动图测量MPI。观察所有患者住院期间MACE的发生率。采用DeLong’s法曲线下面积变化(AUC)、似然比检验(LRT)和连续净重分类改善(cNRI)评价GRACE风险评分单独和联合Tei指数的增量预测值。结果:GRACE风险评分中加入Tei指数显著提高了GRACE风险评分的预测价值(AUC由GRACE风险评分的0.753增加到GRACE评分联合Tei指数的0.801,p=0.354;轻轨车= 4.65,p = 0.030;cNRI = 0.515, p = 0.046)。结论:将Tei指数调整为GRACE风险评分可提高AMI后院内MACE的风险预测。
The role of Tei index added to the GRACE risk score for prediction of in-hospital MACE after acute myocardial infarction.
Introduction: The Global Registry of Acute Coronary Events (GRACE) risk score is widely recommended for risk assessment in patients with acute myocardial infarction (AMI). Variable degrees of impairment in left ventricular (LV) systolic and diastolic function might be found after AMI. Tei index is an echocardiography parameter that represents both systolic and diastolic LV performance. Previous studies demonstrate Tei index as an independent predictor of Major Adverse Cardiovascular Events (MACE) after AMI. This study investigates whether the addition of Tei index could improve the GRACE risk score performance to predict inhospital MACE after AMI. Methods: A prospective cohort study was conducted on 75 patients who presented with AMI. Total GRACE score was calculated on patient admission and echocardiography was conducted within 72 hours of hospitalization for measurement of MPI. All patients were observed for the incidence of MACE during hospitalization. The incremental predictive value of the GRACE risk score alone and combined with Tei index was assessed by the change in area under the curve (AUC) by DeLong's method, likelihood ratio test (LRT), and continuous net reclassification improvement (cNRI). Results: The addition of Tei index to the GRACE risk score significantly improves the predictive value of the GRACE risk score (increase in AUC from 0.753 for the GRACE risk score to 0.801 for the GRACE score combine with Tei index, p=0.354; LRT=4.65, p=0.030; cNRI=0.515, p=0.046). Conclusions: Adjustment of Tei index to GRACE risk score might improve risk prediction of in-hospital MACE after AMI.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.