经皮电刺激PC5和PC6穴位增加健康受试者交感迷走神经平衡但不增加氧化应激:一项随机临床试验

IF 0.9 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE
Fernando Gomes de Jesus, Alice Pereira Duque, Carole Sant, Ana Massolar, Giselle Pinto de Faria Lopes, Ana Carolina de Azevedo Carvalho, Mauro Felippe Felix Mediano, Luiz Fernando Rodrigues
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引用次数: 2

摘要

背景:经皮穴位电刺激(TEAS)可改善慢性疾病患者的自主神经平衡,降低氧化应激,从而降低低级别慢性炎症性疾病(包括心血管疾病)的风险。然而,这些有益效果从未在健康受试者中得到证实。目的:评价茶对健康受试者自主神经平衡和氧化应激的急性影响。方法:采用随机临床试验方法,选取健康男性(18-30岁),随机分为对照组(无干预组;N = 14)、安慰剂(安慰剂干预;n = 14)和tea组(PC5和PC6穴位;N = 13)。该方案包括适应(20分钟)、干预(40分钟)和恢复(30分钟)三个阶段。通过心率、血压和双产物的测定,研究了tea对血流动力学的急性影响;通过心率变异性评估自主神经系统;并通过定量唾液样本中的活性氧,在每个周期结束时收集氧化应激。结果:与对照组和安慰剂组相比,tea组心率和双产物增加(p < 0.01)。此外,与对照组和安慰剂组相比,tea增加了交感神经张力,减少了副交感神经张力,增加了交感迷走神经平衡。然而,tea对唾液样本的氧化应激没有影响。结论:在健康受试者中,PC5和PC6穴位的tea可显著改善自主神经平衡,增加交感神经张力,减少副交感神经张力,但对血流动力学反应的改善作用不大。由于它对氧化应激没有影响,因此是否可以作为一种心脏保护策略仍不确定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transcutaneous Electrical Nerve Stimulation of PC5 and PC6 Acupoints Increases Sympathovagal Balance but Not Oxidative Stress in Healthy Subjects: A Randomized Clinical Trial.

Background: Transcutaneous electrical acupoint stimulation (TEAS) improves autonomic balance and reduces oxidative stress in subjects with chronic diseases, that decreases the risk of low-grade chronic inflammatory diseases, including cardiovascular diseases. However, these beneficial effects have never been demonstrated in healthy subjects. Objectives: To evaluate the acute effects of TEAS on autonomic balance and oxidative stress of healthy subjects.

Methods: A randomized clinical trial was conducted with male healthy subjects (18-30 years old), randomly allocated to control (no intervention; n = 14), placebo (placebo intervention; n = 14) and TEAS group (at PC5 and PC6 acupoints; n = 13). The protocol consisted of accommodation (20 min), intervention (40 min), and recovery (30 min) periods. The acute effects of TEAS on hemodynamics were studied through measurements of heart rate, blood pressure and double product; on the autonomic nervous system by assessing heart rate variability; and on oxidative stress by quantifying reactive oxygen species in saliva samples, collected at the end of each period.

Results: TEAS increased heart rate and double-product compared to control and placebo groups (p < 0.01). Moreover, TEAS increased sympathetic and reduced parasympathetic tonus, increasing the sympathovagal balance compared to the control and placebo groups. However, TEAS exerted no effect on oxidative stress in saliva samples.

Conclusion: In healthy subjects, TEAS at PC5 and PC6 acupoints acutely improved autonomic balance, increasing sympathetic and reducing parasympathetic tonus, reflecting little improvement on hemodynamic responses. Whether it could be used as a cardioprotective strategy remains uncertain since it exerted no effect on oxidative stress.

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来源期刊
Journal of Acupuncture and Meridian Studies
Journal of Acupuncture and Meridian Studies INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
1.50
自引率
10.00%
发文量
35
审稿时长
12 weeks
期刊介绍: The Journal of Acupuncture and Meridian Studies is a quarterly, peer-reviewed journal featuring high-quality studies related to basic and clinical acupuncture and meridian research. It also includes new paradigm of integrative research, covering East–West and traditional–modern medicine. Manuscripts should fall into one of the categories: topical review, original research paper, brief ... click here for full Aims & Scope The Journal of Acupuncture and Meridian Studies is a quarterly, peer-reviewed journal featuring high-quality studies related to basic and clinical acupuncture and meridian research. It also includes new paradigm of integrative research, covering East–West and traditional–modern medicine.
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