克拉德滨治疗多发性硬化症后急性特异性肝损伤:首例报告及相关肝脏疾病回顾。

Lorenzo Saraceno, Fiammetta Pirro, Rosa Stigliano, Elio Clemente Agostoni, Alessandra Protti
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引用次数: 5

摘要

近年来,已经开发了几种用于治疗多发性硬化症(MS)的疾病修饰疗法。克拉宾短暂地消耗B淋巴细胞和T淋巴细胞,随后细胞逐渐恢复。文献中未见克拉德里滨药物性肝损伤(DILI)的病例报道。我们描述的情况下,一个19岁的妇女谁发展急性特异性肝损伤后12天与克拉宾治疗。上市后不良事件报告对于早期识别和治疗至关重要。此外,评估药物性肝毒性的生理病理机制可以为临床医生提供有价值的预防和治疗手段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acute idiosyncratic liver injury after Cladribine treatment for multiple sclerosis: first case report and review on associated hepatic disorders.

In recent years, several disease-modifying therapies have been developed for the treatment of multiple sclerosis (MS). Cladribine transiently depletes B and T lymphocytes, with subsequent gradual cell recovery. No cases are reported in literature describing Cladribine drug-induced liver injury (DILI). We describe the case of a 19-year-old woman who developed acute idiosyncratic liver injury 12 days after treatment with Cladribine. Post-marketing adverse event reporting is of paramount importance to allow an early recognition and treatment. Moreover, evaluation of the physiopathological mechanism underlying drug-induced hepatic toxicity can provide clinicians with valuable instruments for prevention and treatment.

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