{"title":"所有抗cd20单克隆抗体具有相似的疗效和风险:评论。","authors":"Ian Dimaandal, Jaime Imitola","doi":"10.1177/13524585221122219","DOIUrl":null,"url":null,"abstract":"The progress in understanding the pathophysiology of multiple sclerosis (MS) by recognizing the role of B-cells has led to a paradigm shift in managing MS. The role of B-cells is supported by the detection of intrathecal immunoglobulins, brain-specific antibodies, B-cells in the meninges, and the cerebrospinal fluid in MS patients.1 In addition to the results of prospective trials targeting CD20, a non-glycosylated transmembrane protein is predominantly found on the surface of B-cells2 and recently identified in about 3%–5% of T-cells.3","PeriodicalId":520714,"journal":{"name":"Multiple sclerosis (Houndmills, Basingstoke, England)","volume":" ","pages":"1847-1848"},"PeriodicalIF":0.0000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"All anti-CD20 monoclonal antibodies have similar efficacy and risks: Commentary.\",\"authors\":\"Ian Dimaandal, Jaime Imitola\",\"doi\":\"10.1177/13524585221122219\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The progress in understanding the pathophysiology of multiple sclerosis (MS) by recognizing the role of B-cells has led to a paradigm shift in managing MS. The role of B-cells is supported by the detection of intrathecal immunoglobulins, brain-specific antibodies, B-cells in the meninges, and the cerebrospinal fluid in MS patients.1 In addition to the results of prospective trials targeting CD20, a non-glycosylated transmembrane protein is predominantly found on the surface of B-cells2 and recently identified in about 3%–5% of T-cells.3\",\"PeriodicalId\":520714,\"journal\":{\"name\":\"Multiple sclerosis (Houndmills, Basingstoke, England)\",\"volume\":\" \",\"pages\":\"1847-1848\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Multiple sclerosis (Houndmills, Basingstoke, England)\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/13524585221122219\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Multiple sclerosis (Houndmills, Basingstoke, England)","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/13524585221122219","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
All anti-CD20 monoclonal antibodies have similar efficacy and risks: Commentary.
The progress in understanding the pathophysiology of multiple sclerosis (MS) by recognizing the role of B-cells has led to a paradigm shift in managing MS. The role of B-cells is supported by the detection of intrathecal immunoglobulins, brain-specific antibodies, B-cells in the meninges, and the cerebrospinal fluid in MS patients.1 In addition to the results of prospective trials targeting CD20, a non-glycosylated transmembrane protein is predominantly found on the surface of B-cells2 and recently identified in about 3%–5% of T-cells.3
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