利用科学发现开发治疗休眠乳腺癌细胞的策略。

Oncoscience Pub Date : 2022-09-13 eCollection Date: 2022-01-01 DOI:10.18632/oncoscience.562
Alejandra Ferrer, Yannick Kenfack, Andrew Petryna, Wadih Arap, Renata Pasqualini, Pranela Rameshwar
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引用次数: 0

摘要

乳腺癌(BC)转移可能发生在临床诊断前几十年。在此期间,癌细胞(bcc)可以休眠数十年。这种类型的休眠也发生在缓解期,此时休眠的bcc在组织微环境中适应循环静止。BC以骨髓(BM)为主,预后较差。由于外周界面和内皮之间复杂的生态位,基底膜提供了一个挑战。休眠过程在进入骨髓后开始,通过癌细胞和组织生态位之间的串扰促进了变化。更重要的是,休眠可以发生在疾病过程中的任何时间,包括治疗期间。这一观点讨论了骨髓微环境对开发治疗所带来的挑战。本文讨论了骨髓生态位内各区室的复杂机制以及对内源性干细胞的毒性增加的负面问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Leveraging the scientific findings to develop therapeutic strategies for dormant breast cancer cells.

Leveraging the scientific findings to develop therapeutic strategies for dormant breast cancer cells.

Breast cancer (BC) metastasis can occur decades before clinical diagnosis. During this time, the cancer cells (BCCs) can remain dormant for decades. This type of dormancy also occurs during remission where the dormant BCCs adapt cycling quiescence within the tissue microenvironment. BC shows preference for the bone marrow (BM), resulting in poor prognosis. The BM provides a challenge due to the complex niche between the peripheral interface and endosteum. The process of dormancy begins upon entry into the marrow with the changes facilitated through crosstalk between the cancer cells and tissue niche. More importantly, dormancy can occur at any time during the disease process, including the time during treatment. This perspective discusses the challenges posed by the marrow microenvironment to develop treatment. The article discusses the complex mechanisms at each compartment within the marrow niche and the added negative issue of toxicity to the endogenous stem cells.

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