极其复杂的迷宫结构:对分泌性脑膜瘤中发现的奇特质膜内陷的电子显微镜观察。

IF 1.1 Q4 ONCOLOGY
International journal of clinical and experimental pathology Pub Date : 2022-08-15 eCollection Date: 2022-01-01
Masayuki Shintaku
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引用次数: 0

摘要

在对一名73岁男子的蝶骨脊分泌性脑膜瘤进行电子显微镜检查时,观察到了巨大、极其复杂的迷宫状结构。在许多肿瘤细胞中,这些迷宫状结构在细胞质内形成圆形区域,剖面显示其内部结构由许多薄薄的细胞质碎片和中间的絮状物质组成。这些迷宫状结构与假咽瘤体没有明显的地形关联,很少观察到它们通过非常细的通道与细胞外空间直接沟通。这些结构类似于上皮瘤中常见的 "胞质内腔";但它们似乎并不是真正的 "胞质内 "封闭结构,而是质膜向细胞质的深层精细侵入。这些结构有别于假性炎瘤体,可能是这一亚型脑膜瘤中肿瘤细胞上皮特性的另一种表现形式。虽然它们的发病机制或意义尚不清楚,但这些结构可能会大大增加肿瘤细胞的表面积,促进细胞外物质的吸收。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Extremely intricate labyrinthine structures: an electron microscopic observation of peculiar invaginations of the plasma membrane found in secretory meningioma.

Large, extremely intricate labyrinthine structures were observed during an electron microscopic examination of a secretory meningioma that originated in the sphenoid ridge of a 73-year-old man. In many neoplastic cells, these labyrinthine structures formed round-shaped regions within the cytoplasm, and profiles indicated their internal structure consisted of numerous thin fragments of cytoplasm and intervening flocculent material. These labyrinthine structures did not exhibit apparent topographic association with pseudopsammoma bodies, and direct communication with the extracellular space by very thin channels was rarely observed. The structures resembled the "intracytoplasmic lumina" commonly seen in epithelial neoplasms; but they did not appear to be true "intracytoplasmic" closed structures but rather deep and elaborate invaginations of the plasma membrane into the cytoplasm. These structures are distinct from pseudopsammoma bodies and might represent another expression of the epithelial properties of neoplastic cells in this subtype of meningioma. Although their pathogenesis or significance remain unknown, these structures may significantly increase the surface area of neoplastic cells and facilitate the uptake of extracellular material.

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来源期刊
自引率
0.00%
发文量
42
审稿时长
1 months
期刊介绍: The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.
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