过渡金属与粪肠球菌:内稳态、毒力与展望。

IF 2.8 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Molecular Oral Microbiology Pub Date : 2022-12-01 Epub Date: 2022-09-26 DOI:10.1111/omi.12391
Islam A A Ali, Gary S P Cheung, Prasanna Neelakantan
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引用次数: 1

摘要

粪肠球菌是一种革兰氏阳性细菌,已知是几种慢性感染以及医院感染、心脏瓣膜感染、尿路感染、手术伤口感染和牙根管感染的关键因素。感知不同过渡金属水平并相应地调整其反应的能力赋予了它茁壮成长的潜力,并在几个宿主壁龛中引起感染。在过去的十年中,我们对过渡金属如何在维持粪肠杆菌稳态中发挥关键作用的认识有了显著提高。本文旨在阐明铁、锰、锌、铜等金属在粪肠杆菌的生理、代谢和致病性中的作用。这些必需微量营养素有助于能量产生、氧化还原应激反应、毒力决定因素的表达以及多微生物群落的合作。该综述还强调了粪肠杆菌中的金属稳态系统,该系统对细胞外金属水平的波动作出反应,并调节细胞内金属含量。细胞内金属组的调节确保了粪肠杆菌对氧化应激和宿主介导的金属隔离策略的耐受性。已经提出了通过剥夺粪肠杆菌对必需金属的需求或破坏其稳态控制的治疗干预措施来对抗粪肠杆菌感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transition metals and Enterococcus faecalis: Homeostasis, virulence and perspectives.

Enterococcus faecalis, a Gram-positive bacterium, is known to be a key player in several chronic infections as well as nosocomial, heart valve, urinary tract, surgical wound, and dental root canal infections. The capability to sense different transition metal levels and tune its response accordingly endows it with the potential to thrive and cause infections in several host niches. Over the past decade, our knowledge of how transition metals play a critical role in maintaining homeostasis of E. faecalis has improved significantly. The aim of this review is to elucidate the roles of metals such as iron, manganese, zinc, and copper in the physiology, metabolism, and pathogenicity of E. faecalis. These essential micronutrients contribute to energy production, redox stress response, expression of virulence determinants, and cooperation in polymicrobial communities. The review also highlights metal homeostasis systems in E. faecalis, which respond to fluctuations in extracellular metal levels, and regulate the intracellular metal content. Regulation of intracellular metallome secures the tolerance of E. faecalis to oxidative stress and host-mediated metal sequestration strategies. Therapeutic interventions which deprive E. faecalis of its essential metal requirements or disrupt its homeostatic control have been proposed to combat E. faecalis infections.

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来源期刊
Molecular Oral Microbiology
Molecular Oral Microbiology DENTISTRY, ORAL SURGERY & MEDICINE-MICROBIOLOGY
CiteScore
6.50
自引率
5.40%
发文量
46
审稿时长
>12 weeks
期刊介绍: Molecular Oral Microbiology publishes high quality research papers and reviews on fundamental or applied molecular studies of microorganisms of the oral cavity and respiratory tract, host-microbe interactions, cellular microbiology, molecular ecology, and immunological studies of oral and respiratory tract infections. Papers describing work in virology, or in immunology unrelated to microbial colonization or infection, will not be acceptable. Studies of the prevalence of organisms or of antimicrobials agents also are not within the scope of the journal. The journal does not publish Short Communications or Letters to the Editor. Molecular Oral Microbiology is published bimonthly.
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