Nariman Nassiri, Shibandri Das, Vaama Patel, Aravindh Nirmalan, Dhir Patwa, Alexandra Heriford, Chaesik Kim, Haoxing Chen, Faisal Ridha, Justin Tannir, Anju Goyal, Mark S Juzych, Bret A Hughes
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Eyes with glaucoma-determined by two consecutive, reliable visual field tests-were excluded, as well as any eyes with any clinically significant retinal or neurological disease. The percentage of glaucoma suspect eyes, which progressed to glaucoma within a 5-year period, was calculated. Study subjects were divided into the following groups: eyes that progressed to glaucoma and those that did not.</p><p><strong>Results: </strong>In the 288 patients which we looked at, 365 total eyes, 323 eyes had concerning cup-to-disk ratio and 42 had ocular hypertension. Bivariate analysis showed that the eyes which progressed to glaucoma had significantly worse mean deviation, increased pattern standard deviation (PSD), and less visual field index (VFI). Our bivariate analysis also showed a thinner average, superior and inferior retinal nerve fiber layer thickness (RNFL), and more severe average, superior, and inferior RNFL damages (i.e., color grading scale) at baseline. Logistic regression analysis showed that only PSD and severe inferior RNFL damage (i.e., red color) to be significantly associated with 5-year glaucomatous progression.</p><p><strong>Conclusion: </strong>Segmental RNFL damage and pattern standard deviation are associated with 5-year glaucomatous progression in glaucoma suspect eyes.</p><p><strong>How to cite this article: </strong>Nassiri N, Das S, Patel V, <i>et al.</i> Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study. 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引用次数: 0
摘要
目的:利用人口统计学、临床、视野和光学相干断层扫描(OCT)等变量研究疑似青光眼患者5年青光眼进展的相关性。患者和方法:这是一项回顾性纵向临床研究。纳入标准为疑似青光眼(即杯盘比和/或眼压>21 mm Hg)，年龄≥30岁，随访时间5年，最佳矫正视力(BCVA)为20/100及以上，球形当量(SE)大于8屈光度，散光小于3屈光度。排除青光眼(由连续两次可靠的视野测试确定)，以及任何具有临床意义的视网膜或神经系统疾病的眼睛。计算5年内发展为青光眼的疑似青光眼的百分比。研究对象被分为以下两组:发展为青光眼的眼睛和未发展为青光眼的眼睛。结果:288例患者共365只眼，杯盘比异常323只眼，高眼压42只眼。双变量分析结果显示，进展为青光眼的平均偏差明显变差，模式标准差(PSD)增加，视野指数(VFI)降低。我们的双变量分析还显示，视网膜神经纤维层平均、上、下厚度(RNFL)更薄，平均、上、下RNFL损伤(即颜色分级量表)在基线时更严重。Logistic回归分析显示，只有PSD和严重的下RNFL损伤(即红色)与5年青光眼进展显著相关。结论:疑似青光眼患者5年青光眼进展与节段性RNFL损伤及模式标准差相关。如何引用本文:Nassiri N, Das S, Patel V等。青光眼可疑眼5年青光眼进展相关因素:一项回顾性纵向研究。中华青光眼杂志;2010;16(1):11-16。
Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study.
Purpose: Using demographic, clinical, visual field, and optical coherence tomography (OCT) variables to study the association of 5-year glaucomatous progression in glaucoma suspect eyes.
Patients and methods: This is a retrospective longitudinal clinical study. Inclusion criteria consisted of glaucoma suspect eyes (i.e., concerning cup-to-disk ratio and/or intraocular pressure (IOP) >21 mm Hg), age ≥ 30 years old, follow-up time of 5 years, best-corrected visual acuity (BCVA) of 20/100 or better, spherical equivalent (SE) higher than 8 diopters and an astigmatism less than 3 diopters. Eyes with glaucoma-determined by two consecutive, reliable visual field tests-were excluded, as well as any eyes with any clinically significant retinal or neurological disease. The percentage of glaucoma suspect eyes, which progressed to glaucoma within a 5-year period, was calculated. Study subjects were divided into the following groups: eyes that progressed to glaucoma and those that did not.
Results: In the 288 patients which we looked at, 365 total eyes, 323 eyes had concerning cup-to-disk ratio and 42 had ocular hypertension. Bivariate analysis showed that the eyes which progressed to glaucoma had significantly worse mean deviation, increased pattern standard deviation (PSD), and less visual field index (VFI). Our bivariate analysis also showed a thinner average, superior and inferior retinal nerve fiber layer thickness (RNFL), and more severe average, superior, and inferior RNFL damages (i.e., color grading scale) at baseline. Logistic regression analysis showed that only PSD and severe inferior RNFL damage (i.e., red color) to be significantly associated with 5-year glaucomatous progression.
Conclusion: Segmental RNFL damage and pattern standard deviation are associated with 5-year glaucomatous progression in glaucoma suspect eyes.
How to cite this article: Nassiri N, Das S, Patel V, et al. Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study. J Curr Glaucoma Pract 2022;16(1):11-16.
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