雷替重力韦和利福平在暴露于活动性结核的艾滋病毒婴儿中的药代动力学相互作用:一个病例报告。

IF 1.3 4区医学 Q4 INFECTIOUS DISEASES

Antiviral Therapy Pub Date : 2022-08-01 DOI:10.1177/13596535221119932

Marlotte Aa van der Veer, Tom G Jacobs, Laura H Bukkems, Angela Ph Colbers, David M Burger, Henriette J Scherpbier, Yuma A Bijleveld

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引用次数: 2

摘要

我们报告一例婴儿艾滋病毒接受雷替格拉韦颗粒口服混悬液和利福平为基础的结核病预防。尽管使用双剂量雷替格拉韦，但在利福平同时治疗期间，雷替格拉韦谷水平仍处于亚治疗状态，病毒载量增加。即使在利福平治疗后，也需要更高的剂量。这突出了治疗药物监测和调整雷替格拉韦在以利福平为药物的婴儿中的剂量的重要性。

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Pharmacokinetic interaction between raltegravir and rifampicin in an infant with HIV exposed to active TB: a case report.

We report a case of an infant with HIV receiving raltegravir granules for oral suspension and rifampicin-based TB prophylaxis. Raltegravir trough levels remained subtherapeutic and viral load increased during concurrent rifampicin therapy despite using double-dosed raltegravir. Even after rifampicin therapy, a higher dose was needed. This highlights the importance of therapeutic drug monitoring and dose adjustments of raltegravir in infants with rifampicin as comedication.

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来源期刊

Antiviral Therapy 医学-病毒学

CiteScore

2.60

自引率

8.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Antiviral Therapy (an official publication of the International Society of Antiviral Research) is an international, peer-reviewed journal devoted to publishing articles on the clinical development and use of antiviral agents and vaccines, and the treatment of all viral diseases. Antiviral Therapy is one of the leading journals in virology and infectious diseases. The journal is comprehensive, and publishes articles concerning all clinical aspects of antiviral therapy. It features editorials, original research papers, specially commissioned review articles, letters and book reviews. The journal is aimed at physicians and specialists interested in clinical and basic research.