高清晰度经颅直流电与脑中风后运动康复:一项随机对照试验。

IF 3.7 2区 医学 Q1 CLINICAL NEUROLOGY
Yi-Jing Huang, Shun-Min Wang, Chieh Chen, Chien-An Chen, Chun-Wei Wu, Jia-Jin Chen, Chih-Wei Peng, Che-Wei Lin, Shih-Wei Huang, Shih-Ching Chen
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引用次数: 1

摘要

背景:高清晰度经颅电脉冲叠加直流电刺激(HD-tDCS-eTBS)既融合了tDCS和TBS的治疗优势,又增强了刺激的聚焦性和实用性。然而,这种创新的神经调节装置在脑卒中后康复中的适用性仍然不确定。目的:本研究旨在评估HD-tDCS-eTBS对慢性脑卒中患者上肢运动功能的疗效和安全性。方法:采用患者盲法、随机对照研究。24名参与者被随机分为活跃HD-tDCS-eTBS组和假HD-tDCS-eTBS组。两组均接受主动/假HD-tDCS-eTBS治疗,每次20分钟,联合30分钟的常规UE康复治疗,每周3次,连续4周。结果测量包括Fugl-Meyer上肢评估、Wolf运动功能测试、Jebsen-Taylor手功能测试、手指-鼻子测试和改良Ashworth量表在干预前后进行评估。结果:肩部内收肌痉挛(P = 0.05)、肘关节伸肌痉挛(P = 0.04)、拇指屈肌痉挛(P = 0.06)。26, ηp2 = 0.06-0.16)。HD-tDCS-eTBS后,除刺激电极下皮肤轻微发红外,未见严重不良反应。结论:我们的研究结果支持HD-tDCS-eTBS是安全的,并且具有卒中后UE运动康复的治疗潜力。试验注册:ClinicalTrials.gov (ID: NCT04278105)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High-Definition Transcranial Direct Current with Electrical Theta Burst on Post-Stroke Motor Rehabilitation: A Pilot Randomized Controlled Trial.

Background: High-definition transcranial electrical theta burst superimposing direct current stimulation (HD-tDCS-eTBS) not only incorporates the therapeutic advantages of tDCS and TBS but enhances stimulation focality and practicality. However, the applicability of this innovative neuromodulatory device in post-stroke rehabilitation remains uncertain.

Objective: This study aimed to assess the efficacy and safety of the HD-tDCS-eTBS on upper extremity (UE) motor function in patients with chronic stroke.

Methods: A patient-blinded, randomized controlled study was conducted. Twenty-four participants were randomly assigned into either the active HD-tDCS-eTBS group or sham HD-tDCS-eTBS group. Both groups received 20 minutes of active/sham HD-tDCS-eTBS combined with 30 minutes of conventional UE rehabilitation each time, 3 times a week for 4 weeks. Outcome measures including the Fugl-Meyer Assessment of Upper Extremity, Wolf Motor Function Test, Jebsen-Taylor Hand Function Test, Finger-Nose Test, and Modified Ashworth Scale were assessed before and immediately after the intervention period.

Results: Spasticity of shoulder adductor (P = .05), elbow extensor (P = .04), and thumb flexor (P < .01) were significantly reduced in the active HD-tDCS-eTBS group versus the sham group. Nonsignificant trends in the improvements of most other outcome measures were in favor of the active HD-tDCS-eTBS group with moderate to large effect sizes (P = .06-.26, ηp2 = 0.06-0.16). No severe adverse events except for slight skin redness under the stimulus electrode was detected after the HD-tDCS-eTBS.

Conclusions: Our findings support that HD-tDCS-eTBS is safe and has therapeutic potential for post-stroke UE motor rehabilitation.

Trial registration: ClinicalTrials.gov (ID: NCT04278105).

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来源期刊
CiteScore
8.30
自引率
4.80%
发文量
52
审稿时长
6-12 weeks
期刊介绍: Neurorehabilitation & Neural Repair (NNR) offers innovative and reliable reports relevant to functional recovery from neural injury and long term neurologic care. The journal''s unique focus is evidence-based basic and clinical practice and research. NNR deals with the management and fundamental mechanisms of functional recovery from conditions such as stroke, multiple sclerosis, Alzheimer''s disease, brain and spinal cord injuries, and peripheral nerve injuries.
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