分离的髓过氧化物酶-抗中性粒细胞细胞质抗体-相关的肥厚性厚性脑膜炎。

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases Pub Date : 2022-04-01 DOI:10.1097/RHU.0000000000001845

Jeffrey Maneval, Bronwyn Bryant, Adam Ulano, Waqar Waheed, Alana Nevares

{"title":"分离的髓过氧化物酶-抗中性粒细胞细胞质抗体-相关的肥厚性厚性脑膜炎。","authors":"Jeffrey Maneval, Bronwyn Bryant, Adam Ulano, Waqar Waheed, Alana Nevares","doi":"10.1097/RHU.0000000000001845","DOIUrl":null,"url":null,"abstract":"Abstract: A 65-year-old man with no pertinent medical history presented with 1 month of progressive holocephalic positional headaches (worse supine), photophobia, progressive gait instability resulting in multiple falls (ambulatory to walker in only 2 months), and weight loss. Testing found positive ANCA 1:160 perinuclear patter, myeloperoxidase >8.0. Cerebrospinal fluid found lymphocytic pleocytosis. We present his neuroimaging of isolated hypertrophic pachymeningitis with clinicoradiographic resolution after immunomodulatory pharmacotherapy along with histology from his meningeal biopsy. Isolated vasculitic myeloperoxidase-antineutrophil cytoplasmic antibody hypertrophic pachymeningitis is quite rare.","PeriodicalId":520664,"journal":{"name":"Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases","volume":" ","pages":"e672-e674"},"PeriodicalIF":0.0000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Isolated Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Hypertrophic Pachymeningitis.\",\"authors\":\"Jeffrey Maneval, Bronwyn Bryant, Adam Ulano, Waqar Waheed, Alana Nevares\",\"doi\":\"10.1097/RHU.0000000000001845\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract: A 65-year-old man with no pertinent medical history presented with 1 month of progressive holocephalic positional headaches (worse supine), photophobia, progressive gait instability resulting in multiple falls (ambulatory to walker in only 2 months), and weight loss. Testing found positive ANCA 1:160 perinuclear patter, myeloperoxidase >8.0. Cerebrospinal fluid found lymphocytic pleocytosis. We present his neuroimaging of isolated hypertrophic pachymeningitis with clinicoradiographic resolution after immunomodulatory pharmacotherapy along with histology from his meningeal biopsy. Isolated vasculitic myeloperoxidase-antineutrophil cytoplasmic antibody hypertrophic pachymeningitis is quite rare.\",\"PeriodicalId\":520664,\"journal\":{\"name\":\"Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases\",\"volume\":\" \",\"pages\":\"e672-e674\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/RHU.0000000000001845\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/RHU.0000000000001845","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

摘要:65岁男性，无相关病史，表现为进行性全头体位性头痛(仰卧位加重)1个月，畏光，进行性步态不稳定导致多次跌倒(仅2个月可行走)，体重下降。检测发现ANCA 1:160核周型阳性，髓过氧化物酶>8.0。脑脊液发现淋巴细胞增多症。我们报告他在免疫调节药物治疗后的孤立性增生性厚性脑膜炎的神经影像学和临床放射学分辨率，以及他脑膜活检的组织学。分离的血管性髓过氧化物酶-抗中性粒细胞细胞质抗体是非常罕见的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Isolated Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Hypertrophic Pachymeningitis.

Abstract: A 65-year-old man with no pertinent medical history presented with 1 month of progressive holocephalic positional headaches (worse supine), photophobia, progressive gait instability resulting in multiple falls (ambulatory to walker in only 2 months), and weight loss. Testing found positive ANCA 1:160 perinuclear patter, myeloperoxidase >8.0. Cerebrospinal fluid found lymphocytic pleocytosis. We present his neuroimaging of isolated hypertrophic pachymeningitis with clinicoradiographic resolution after immunomodulatory pharmacotherapy along with histology from his meningeal biopsy. Isolated vasculitic myeloperoxidase-antineutrophil cytoplasmic antibody hypertrophic pachymeningitis is quite rare.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

自引率

0.00%

发文量