在2021年埃塞俄比亚南部公立医院登记的Implanon使用者队列中,Implanon停药的生存时间及其预测因素:一项回顾性队列研究

Aklilu Habte, Merertu Wondimu, Hanan Abdulkadir
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引用次数: 2

摘要

背景:证据有力地表明,提供高质量的计划生育服务伴随着避孕药具使用的增加和停止避孕药具的减少。避孕,特别是中止计划生育是一个全球性的问题,可以与计划生育服务质量差的简要结果指标联系起来。尽管Implanon在埃塞俄比亚避孕药具使用者中越来越受欢迎,但人们对停药后的生存和预测因素知之甚少。该研究旨在探讨2021年在埃塞俄比亚南部公立医院计划生育部门登记的妇女中停止注射的存活率和预测因素。方法:采用以医院为基础的回顾性队列研究,对在公立医院计划生育科室就诊的Implanon使用者进行调查。对2016年1月1日至2020年12月30日的5年医疗记录进行了审查。采用随机抽样的方法,共选取了502名女性。使用标准化的抽象工具从病历和登记簿中收集数据。将数据输入Epidata Version 3.1,然后导出到STATA 14进行分析。在生存时间的情况下计算中位数。在协变量中,Kaplan Meier生存曲线用于估计到Implanon停药的时间。为了确定有统计学意义的Implanon停药预测因子,我们拟合了一个多变量Cox比例风险模型。结果:Implanon停药的发生率为1.87 / 100人/月(95% CI = 1.63, 2.15)。24个月和36个月时的总体估计生存率分别为67.4% (95%CI, 62.5, 71.8)和25.9% (95%CI, 18.4, 34.1)个月。居住地[AHR = 1.50;95%CI: 1.09, 2.08],奇偶性[AHR = 2.02;95%CI: 1.65, 3.67],插入前咨询[AHR = 2.41;95%CI: 1.72, 3.70],阴道大量出血[AHR = 3.91;95%CI: 2.67, 5.32],插入后随访[AHR = 3.15;95%CI:2.11, 4.75]被确定为Implanon停药的重要预测因子。结论:停药风险较高,尤其是在24、36个月。在计划生育服务点,卫生保健提供者应特别注意生活在农村地区且没有子女的客户。此外,医疗保健提供者应提供插入前咨询和插入后的随访,重点关注潜在的副作用。最后,计划生育单位需要参与早期副作用管理和保证,以减轻停药。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Survival time to Implanon discontinuation and its predictors among a cohort of Implanon users who enrolled in public hospitals of southern Ethiopia, 2021: a retrospective cohort study.

Survival time to Implanon discontinuation and its predictors among a cohort of Implanon users who enrolled in public hospitals of southern Ethiopia, 2021: a retrospective cohort study.

Survival time to Implanon discontinuation and its predictors among a cohort of Implanon users who enrolled in public hospitals of southern Ethiopia, 2021: a retrospective cohort study.

Survival time to Implanon discontinuation and its predictors among a cohort of Implanon users who enrolled in public hospitals of southern Ethiopia, 2021: a retrospective cohort study.

Background: Pieces of evidence strongly indicate that providing high-quality family planning services is accompanied by an increase in contraceptive uptake and a decrease in contraception discontinuation. Contraceptive, especially Implanon discontinuation is a global issue that could be linked to a summary outcome indicator of poor family planning service quality. Although Implanon is becoming more popular among Ethiopian contraceptive users, little is known regarding the survival and predictors of discontinuation. The study aimed at exploring the survival and predictors of Implanon discontinuation among women enrolled in family planning units of Public hospitals in southern Ethiopia, 2021.

Methods: A hospital-based retrospective cohort study was conducted among Implanon users who enrolled in family planning units of Public Hospitals. Five years of medical records, from January 1, 2016, to December 30, 2020, were reviewed. A total of 502 women were selected by using a random sampling technique. A standardized abstraction tool was used to collect data from medical records and registration books. The data were entered into Epidata Version 3.1 and then exported to STATA 14 for analysis. The median was calculated in the case of survival time. Across covariates, the Kaplan Meier survival curve was used to estimate time to Implanon discontinuation. To identify statistically significant predictors of Implanon discontinuation, a multivariable Cox proportional hazard model was fitted.

Results: The incidence rate of Implanon discontinuation was 1.87(95% CI = 1.63, 2.15) per 100 person-months of observation. The overall estimated survival probability at the end of 24 and 36 months was 67.4% (95%CI, 62.5, 71.8) and 25.9% (95%CI, 18.4, 34.1) months respectively. Residence [AHR = 1.50; 95%CI: 1.09, 2.08], parity [AHR = 2.02; 95%CI: 1.65, 3.67], pre-insertion counselling [AHR = 2.41; 95%CI: 1.72, 3.70], experiencing heavy vaginal bleeding [AHR = 3.91; 95%CI: 2.67, 5.32], post-insertion follow up [AHR = 3.15; 95%CI:2.11, 4.75] were identified as a significant predictors of Implanon discontinuation.

Conclusion: The risk Implanon of discontinuation was high, especially at 24 and 36 months. In family planning service delivery points, health care providers should pay special attention to clients who live in rural areas and do not have children. In addition, health care providers should provide pre-insertion counseling and post-insertion follow-up that focus on potential side effects. Finally, family planning units need to engage in early side effect management and reassurance to mitigate discontinuation.

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