Hong Yang, Zhenyan Fu, Yitong Ma, Ding Huang, Qing Zhu, Cha Erdenbat, Xiang Xie, Fen Liu, Yingying Zheng
{"title":"CYP4A11基因T8590C多态性与中国西部男性汉族原发性高血压相关","authors":"Hong Yang, Zhenyan Fu, Yitong Ma, Ding Huang, Qing Zhu, Cha Erdenbat, Xiang Xie, Fen Liu, Yingying Zheng","doi":"10.3109/10641963.2013.846353","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>CYP4A11 is a member of the cytochrome P450 enzymes and is responsible for metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in the regulation of blood pressure. This study aimed to evaluate whether or not the CYP4A11 gene polymorphism T8590C (rs1126742) is involved in essential hypertension in the western Chinese Han population.</p><p><strong>Methods: </strong>In a case-control study, the participants included 864 (523 males and 341 females) patients with essential hypertension and 661 (422 males and 239 females) healthy subjects. The T8590C polymorphism of the CYP4A11 gene was analyzed by using the TaqMan® SNP Genotyping Assay.</p><p><strong>Results: </strong>For men, the frequencies of the CC genotype and the C allele were higher in essential hypertension than in the control group (p=0.022 and p=0.016, respectively). After adjustment of confounding factor such as diabetes, smoking, BMI, TG and TC, the significant difference was observed in CC genotype (OR=1.897, 95% confidence interval [CI] 1.026-3.508; p=0.041). No difference was found in all participants and females.</p><p><strong>Conclusions: </strong>The CC genotype and C allele were associated with essential hypertension in the male western Chinese Han population.</p>","PeriodicalId":286988,"journal":{"name":"Clinical and Experimental Hypertension (New York, N.y. : 1993)","volume":" ","pages":"398-403"},"PeriodicalIF":0.0000,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641963.2013.846353","citationCount":"13","resultStr":"{\"title\":\"CYP4A11 gene T8590C polymorphism is associated with essential hypertension in the male western Chinese Han population.\",\"authors\":\"Hong Yang, Zhenyan Fu, Yitong Ma, Ding Huang, Qing Zhu, Cha Erdenbat, Xiang Xie, Fen Liu, Yingying Zheng\",\"doi\":\"10.3109/10641963.2013.846353\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>CYP4A11 is a member of the cytochrome P450 enzymes and is responsible for metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in the regulation of blood pressure. This study aimed to evaluate whether or not the CYP4A11 gene polymorphism T8590C (rs1126742) is involved in essential hypertension in the western Chinese Han population.</p><p><strong>Methods: </strong>In a case-control study, the participants included 864 (523 males and 341 females) patients with essential hypertension and 661 (422 males and 239 females) healthy subjects. The T8590C polymorphism of the CYP4A11 gene was analyzed by using the TaqMan® SNP Genotyping Assay.</p><p><strong>Results: </strong>For men, the frequencies of the CC genotype and the C allele were higher in essential hypertension than in the control group (p=0.022 and p=0.016, respectively). After adjustment of confounding factor such as diabetes, smoking, BMI, TG and TC, the significant difference was observed in CC genotype (OR=1.897, 95% confidence interval [CI] 1.026-3.508; p=0.041). No difference was found in all participants and females.</p><p><strong>Conclusions: </strong>The CC genotype and C allele were associated with essential hypertension in the male western Chinese Han population.</p>\",\"PeriodicalId\":286988,\"journal\":{\"name\":\"Clinical and Experimental Hypertension (New York, N.y. : 1993)\",\"volume\":\" \",\"pages\":\"398-403\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/10641963.2013.846353\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Experimental Hypertension (New York, N.y. : 1993)\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3109/10641963.2013.846353\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2013/10/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Hypertension (New York, N.y. : 1993)","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3109/10641963.2013.846353","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2013/10/28 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
CYP4A11 gene T8590C polymorphism is associated with essential hypertension in the male western Chinese Han population.
Background: CYP4A11 is a member of the cytochrome P450 enzymes and is responsible for metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in the regulation of blood pressure. This study aimed to evaluate whether or not the CYP4A11 gene polymorphism T8590C (rs1126742) is involved in essential hypertension in the western Chinese Han population.
Methods: In a case-control study, the participants included 864 (523 males and 341 females) patients with essential hypertension and 661 (422 males and 239 females) healthy subjects. The T8590C polymorphism of the CYP4A11 gene was analyzed by using the TaqMan® SNP Genotyping Assay.
Results: For men, the frequencies of the CC genotype and the C allele were higher in essential hypertension than in the control group (p=0.022 and p=0.016, respectively). After adjustment of confounding factor such as diabetes, smoking, BMI, TG and TC, the significant difference was observed in CC genotype (OR=1.897, 95% confidence interval [CI] 1.026-3.508; p=0.041). No difference was found in all participants and females.
Conclusions: The CC genotype and C allele were associated with essential hypertension in the male western Chinese Han population.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
