Emily Gibbons, Daniel Whittam, Kariem Elhadd, Maneesh Bhojak, Nitika Rathi, Shivaram Avula, Anu Jacob, Michael Griffiths, Saif Huda
{"title":"进行性髓鞘少突胶质细胞糖蛋白相关脱髓鞘模拟白质营养不良。","authors":"Emily Gibbons, Daniel Whittam, Kariem Elhadd, Maneesh Bhojak, Nitika Rathi, Shivaram Avula, Anu Jacob, Michael Griffiths, Saif Huda","doi":"10.1177/13524585221090737","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) may be associated with relapsing disease, but clinical progression independent of relapse activity is rare.</p><p><strong>Objectives: </strong>To report progressive disease in a patient with MOGAD.</p><p><strong>Methods: </strong>A single retrospective case report.</p><p><strong>Results: </strong>At 4 years of age, the patient had a single episode of acute disseminated encephalomyelitis. She remained well until age 17 years but over the next 9 years developed progressive spastic quadriparesis, cognitive and bulbar dysfunction. Brain imaging showed a leukodystrophy-like pattern of white matter abnormality with contrast enhancement at different time points. Myelin oligodendrocyte glycoprotein (MOG)-IgG was repeatedly positive by live cell-based assay.</p><p><strong>Conclusion: </strong>Secondary progression may be a rare presentation of MOG-IgG-associated disease.</p>","PeriodicalId":520714,"journal":{"name":"Multiple sclerosis (Houndmills, Basingstoke, England)","volume":" ","pages":"1481-1484"},"PeriodicalIF":5.0000,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Progressive myelin oligodendrocyte glycoprotein-associated demyelination mimicking leukodystrophy.\",\"authors\":\"Emily Gibbons, Daniel Whittam, Kariem Elhadd, Maneesh Bhojak, Nitika Rathi, Shivaram Avula, Anu Jacob, Michael Griffiths, Saif Huda\",\"doi\":\"10.1177/13524585221090737\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) may be associated with relapsing disease, but clinical progression independent of relapse activity is rare.</p><p><strong>Objectives: </strong>To report progressive disease in a patient with MOGAD.</p><p><strong>Methods: </strong>A single retrospective case report.</p><p><strong>Results: </strong>At 4 years of age, the patient had a single episode of acute disseminated encephalomyelitis. She remained well until age 17 years but over the next 9 years developed progressive spastic quadriparesis, cognitive and bulbar dysfunction. Brain imaging showed a leukodystrophy-like pattern of white matter abnormality with contrast enhancement at different time points. Myelin oligodendrocyte glycoprotein (MOG)-IgG was repeatedly positive by live cell-based assay.</p><p><strong>Conclusion: </strong>Secondary progression may be a rare presentation of MOG-IgG-associated disease.</p>\",\"PeriodicalId\":520714,\"journal\":{\"name\":\"Multiple sclerosis (Houndmills, Basingstoke, England)\",\"volume\":\" \",\"pages\":\"1481-1484\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2022-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Multiple sclerosis (Houndmills, Basingstoke, England)\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/13524585221090737\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/6/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Multiple sclerosis (Houndmills, Basingstoke, England)","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/13524585221090737","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/6/23 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Background: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) may be associated with relapsing disease, but clinical progression independent of relapse activity is rare.
Objectives: To report progressive disease in a patient with MOGAD.
Methods: A single retrospective case report.
Results: At 4 years of age, the patient had a single episode of acute disseminated encephalomyelitis. She remained well until age 17 years but over the next 9 years developed progressive spastic quadriparesis, cognitive and bulbar dysfunction. Brain imaging showed a leukodystrophy-like pattern of white matter abnormality with contrast enhancement at different time points. Myelin oligodendrocyte glycoprotein (MOG)-IgG was repeatedly positive by live cell-based assay.
Conclusion: Secondary progression may be a rare presentation of MOG-IgG-associated disease.
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