家族性地中海热患者对氧磷酶-1、丙二醛和平均血小板体积与动脉粥样硬化标志物的关系:一项观察性研究。

Özlem Karakurt Arıtürk, Kemal Üreten, Münevver Sarı, Nuray Yazıhan, Ezgi Ermiş, İmge Ergüder
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引用次数: 18

摘要

目的:有许多研究表明家族性地中海热(FMF)患者心室和内皮功能恶化。由于FMF是一种具有持续炎症活性的自身炎症性疾病,炎症在一些风湿性疾病的动脉粥样硬化的发生和进展中起着重要作用,我们旨在通过测定血清对氧磷酶-1 (PON-1)活性、平均血小板体积(MPV)和丙二醛(MDA)水平来研究FMF患者动脉粥样硬化的早期标志物。方法:本研究为横断面观察性研究。40名连续的FMF患者和20名健康志愿者被选为研究人群。FMF的诊断基于Tel-Hashomer标准。测定血清PON-1活性、MPV和MDA水平,探讨其与FMF的关系。采用学生t检验、Mann-Whitney U检验、Pearson相关分析进行统计分析。结果:FMF患者PON-1活性明显低于正常人群(141.46±38.29∶179.62±10.73 U/l)。结论:FMF患者PON-1活性明显低于正常人群。PON-1活性降低和MPV升高(独立于这些患者的氧化应激状态)可能导致FMF患者动脉粥样硬化倾向增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship of paraoxonase-1, malondialdehyde and mean platelet volume with markers of atherosclerosis in familial Mediterranean fever: an observational study.

Objective: There are many studies demonstrating deteriorated ventricle and endothelium functions in familial Mediterranean fever (FMF) patients. As FMF is an autoinflammatory disease with an ongoing inflammatory activity and inflammation plays an important role in the development and progression of atherosclerosis in some of the rheumatic diseases, we aimed to investigate the early markers of atherosclerosis in patients with FMF by the measurements of serum paraoxonase-1 (PON-1) activity, mean platelet volume (MPV) and malondialdehyde (MDA) level.

Methods: This study is a cross-sectional, observational study. Forty consecutive patients with FMF and twenty healthy volunteers were selected to form the study population. The diagnosis of FMF was based on Tel-Hashomer criteria. Serum PON-1 activity, MPV and MDA level were determined to examine their association with FMF. Student's t-test, Mann-Whitney U test, Pearson correlation analysis were used for statistical analysis.

Results: The mean PON-1 activity in FMF patients was significantly lower than in the healthy population (141.46±38.29 vs. 179.62±10.73 U/l, p<0.01). Serum MDA levels were the same between the groups (1.08±0.66 vs. 1.08±0.33 nmol/mL, p=0.99). MPV was higher in FMF patients than in the control l group (8.87±0.99 vs. 8.22±0.45 fl, p=0.04). PON, MPV and MDA levels were the same in FMF patients with acute attack and attack -free period.

Conclusion: Our results show that PON-1 activity is lower in patients with FMF. Reduced PON-1 activity and increased MPV, independent of the oxidative stress status of these patients, may lead to increased atherosclerotic propensity in FMF.

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