未经治疗的高血压患者心外膜脂肪组织与左心室质量增加独立相关:一项观察性研究。

Turan Erdoğan, Mustafa Çetin, Sinan Altan Kocaman, Murtaza Emre Durakoğlugil, Elif Ergül, Yavuz Uğurlu, Altun Çanga
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引用次数: 13

摘要

目的:心外膜脂肪组织(EAT)分泌多种炎症介质和生长因子,对心肌和机体具有内分泌和旁分泌作用。我们计划本研究是为了评估EAT和左心室质量(LVM)之间可能的关系,LVM是独立于年龄、血压和高血压患者代谢参数的心血管死亡率和发病率的有效预测因子。方法:本研究是横断面和观察性的,包括连续107例未经治疗的原发性高血压患者,他们接受了完整的经胸超声心动图检查,并测量了LVM和EAT。同时记录血压、血常规、c反应蛋白及患者特征。采用单变量和多元线性回归分析与EAT相关的自变量。结果:LVM与腰围、EAT、血糖、尿酸、高密度脂蛋白(HDL)胆固醇、收缩压和舒张压均有显著相关。当我们根据中位平均血压(BP)将研究人群分为两组(mean BP≤116 vs >116 mmHg)时,EAT是中位血压以下患者LVM的唯一相关因素(Beta值:0.518,p)。结论:在HT患者中,EAT与LVM升高相关,与BMI、腰围、体重、收缩压和舒张压等危险参数无关。通过超声心动图测定增加的EAT可能作为心血管风险和总内脏脂肪组织的指标具有附加价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: an observational study.

Objective: Epicardial adipose tissue (EAT) secretes various inflammatory mediators and growth factor, and has endocrine and paracrine effects on myocardium and body. We planned the present study in order to evaluate the possible relationship between EAT and left ventricular mass (LVM), a potent predictor of cardiovascular mortality and morbidity, independent of age, blood pressure and the metabolic parameters in patients with hypertension (HT).

Methods: The present study was cross-sectional and observational, including consecutive 107 untreated essential hypertensive patients who underwent a complete transthoracic echocardiographic examination as well as measurements of LVM and EAT. Blood pressure, routine blood chemistry, C-reactive protein, and patient characteristics were also recorded. Univariate and then multiple linear regression analyses were used for analysis of independent variables associated with EAT.

Results: LVM significantly correlated with waist circumference, EAT, glucose, uric acid, high-density lipoprotein (HDL) cholesterol, and systolic and diastolic blood pressure. When we divided study population into two groups according to median mean blood pressure (BP) (Mean BP ≤116 vs. >116 mmHg), EAT was the only associated factor for LVM in patients below median BP (Beta: 0.518, p<0.001). Linear regression analyses revealed EAT to be independently associated with LVM (Beta: 0.419; p<0.001) and LVM index (Beta: 0.384, p<0.001) as well as high-density lipoprotein (Beta: -0.264, p=0.006).

Conclusion: EAT was related to increased LVM independent of BMI, waist circumference, weight, systolic and diastolic blood pressure and other risk parameters, in patients with HT. Determination of increased EAT by echocardiography may have an additional value as an indicator of cardiovascular risk and total visceral adipose tissue.

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