Kristoffer M A Henningsen, Morten S Olesen, Golnaz Sajadieh, Stig Haunsoe, Jesper H Svendsen
{"title":"与YKL-40水平升高和早发性房颤风险相关的多态性","authors":"Kristoffer M A Henningsen, Morten S Olesen, Golnaz Sajadieh, Stig Haunsoe, Jesper H Svendsen","doi":"10.1186/1477-5751-12-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF.</p><p><strong>Findings: </strong>We included 178 young patients with lone AF and the first episode before the age of 40 years, and a control group of 875 healthy individuals. We analyzed a promoter SNP (-131CG) (rs4950928) in the Chitinase 3-like 1 (CHI3L1) gene encoding YKL-40, which had previously been associated with elevated levels of YKL-40.</p><p><strong>Conclusions: </strong>The (-131CG) genotype was not associated with increased risk of AF. Genetically increased YKL-40 levels were not associated to AF.</p>","PeriodicalId":73849,"journal":{"name":"Journal of negative results in biomedicine","volume":" ","pages":"1"},"PeriodicalIF":0.0000,"publicationDate":"2013-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1477-5751-12-1","citationCount":"12","resultStr":"{\"title\":\"A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation.\",\"authors\":\"Kristoffer M A Henningsen, Morten S Olesen, Golnaz Sajadieh, Stig Haunsoe, Jesper H Svendsen\",\"doi\":\"10.1186/1477-5751-12-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF.</p><p><strong>Findings: </strong>We included 178 young patients with lone AF and the first episode before the age of 40 years, and a control group of 875 healthy individuals. We analyzed a promoter SNP (-131CG) (rs4950928) in the Chitinase 3-like 1 (CHI3L1) gene encoding YKL-40, which had previously been associated with elevated levels of YKL-40.</p><p><strong>Conclusions: </strong>The (-131CG) genotype was not associated with increased risk of AF. Genetically increased YKL-40 levels were not associated to AF.</p>\",\"PeriodicalId\":73849,\"journal\":{\"name\":\"Journal of negative results in biomedicine\",\"volume\":\" \",\"pages\":\"1\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-01-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1186/1477-5751-12-1\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of negative results in biomedicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/1477-5751-12-1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of negative results in biomedicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/1477-5751-12-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation.
Background: Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF.
Findings: We included 178 young patients with lone AF and the first episode before the age of 40 years, and a control group of 875 healthy individuals. We analyzed a promoter SNP (-131CG) (rs4950928) in the Chitinase 3-like 1 (CHI3L1) gene encoding YKL-40, which had previously been associated with elevated levels of YKL-40.
Conclusions: The (-131CG) genotype was not associated with increased risk of AF. Genetically increased YKL-40 levels were not associated to AF.
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