头颈部透明细胞软骨肉瘤。

Sepideh Mokhtari, Abbas Mirafsharieh
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引用次数: 29

摘要

透明细胞软骨肉瘤是一种罕见的软骨肉瘤,主要累及长骨末端。然而,有9例报告发生在头颈部:4例在喉部,2例在鼻中隔,2例在上颌骨,1例在颅骨。这些案例构成了本次审查的基础。头颈部病例占全身透明细胞软骨肉瘤的不到5%,喉部是最常见的部位。头颈部病例的组织学结果与该实体在全身的一般特征一致,并且该病例系列中几乎所有肿瘤都具有传统软骨肉瘤的成分。透明细胞软骨肉瘤是一种室内肿瘤,在上皮下保留“格伦兹带”。因此,在所有喉部病例中,上覆粘膜保持完整。鼻肿瘤引起鼻中隔肿胀,上颌病变不累及口腔黏膜。该肿瘤在头颈部表现出多种影像学特征。成软骨细胞瘤、软骨瘤、成骨细胞瘤、骨肉瘤和转移性肾细胞癌包括在组织学鉴别诊断中。上颌骨与成软骨骨肉瘤的鉴别是很重要的。在大多数情况下,广泛切除是足够的。然而,一些喉部病例有复发的倾向。透明细胞软骨肉瘤是一种生长缓慢的肿瘤,需要对患者进行长时间的随访。由于在头颈部极为罕见,该区域透明细胞软骨肉瘤的诊断必须通过组织化学和免疫组织化学研究来证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Clear cell chondrosarcoma of the head and neck.

Clear cell chondrosarcoma of the head and neck.

Clear cell chondrosarcoma of the head and neck.

Clear cell chondrosarcoma is a rare variant of chondrosarcoma that mostly involves the end of long bones. However, nine cases have been reported in the head and neck: four in larynx, two in nasal septum, two in maxilla and one in the skull. These cases form the basis of this review. Head and neck cases accounts for less than 5% of Clear cell chondrosarcomas in the whole body and the larynx is the most common place. The histological findings of head and neck cases are consistent with general features of this entity in the whole body and nearly all tumors in this case series had a component of conventional chondrosarcoma. Clear cell chondrosarcoma is an intracompartmental tumor and retains "Grenz zone" just beneath the epithelium. Therefore, the overlying mucosa remained intact in all laryngeal cases. Nasal tumor caused ballooning of the septum and the maxillary lesion did not involve the oral mucosa. This tumor presents various radiographic features in the head and neck area. Chondroblastoma, chondroma, osteoblastoma, osteosarcoma and metastatic renal cell carcinoma are included in the histologic differential diagnoses. Differentiation from chondroblastic osteosarcoma is important in the maxilla. A wide resection is adequate in most cases. However, some laryngeal cases show tendency to recur. Clear cell chondrosarcoma is a slow growing tumor and this necessitates a long time follow-up of patients. Due to the extreme rarity in the head and neck, diagnosis of Clear cell chondrosarcoma in this area, must be confirmed by histochemical and immunohistochemical studies.

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