参与脂肪酸代谢和膳食脂肪摄入的基因多态性之间的关系。

Q Agricultural and Biological Sciences

Journal of Nutrigenetics and Nutrigenomics Pub Date : 2012-01-01 Epub Date: 2012-03-08 DOI:10.1159/000336511

Annie Bouchard-Mercier, Ann-Marie Paradis, Louis Pérusse, Marie-Claude Vohl

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引用次数: 8

摘要

背景:肥胖患病率在我国人口中呈增长趋势。双胞胎研究估计饮食摄入的遗传率约为30%。本研究的目的是验证参与脂肪酸代谢的基因多态性是否与膳食脂肪摄入量有关。方法:招募了700名参与者。一份经过验证的食物频率问卷用于评估膳食摄入量。采用PCR-RFLP和TAQMAN方法对PPARα Leu162Val、PPARγ Pro12Ala、PPARδ -87T>C、PPARα Gly482Ser、FASN Val1483Ile和SREBF1 C .*619C>G进行基因分型。采用SAS统计软件包进行统计分析。结果:携带PPARγ Pro12Ala多态性的Ala12等位基因的人总脂肪摄入量较高(p = 0.04)。对于FASN Val1483Ile多态性，总脂肪和饱和脂肪摄入量存在显著的基因-性别互作效应(p = 0.02和p = 0.002)。脂肪摄入量对ppar1 α Leu162Val、ppar1 δ -87T>C、ppar1 α Gly482Ser和SREBF1 C .*619C>G多态性无显著影响。结论:PPARγ和FASN的多态性似乎与膳食脂肪摄入量有关。在研究饮食摄入量时，基因变异是很重要的考虑因素。

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Associations between polymorphisms in genes involved in fatty acid metabolism and dietary fat intakes.

Background: Obesity prevalence is growing in our population. Twin studies have estimated the heritability of dietary intakes to about 30%. The objective of this study was to verify whether polymorphisms in genes involved in fatty acid metabolism are associated with dietary fat intakes.

Methods: Seven hundred participants were recruited. A validated food frequency questionnaire was used to assess dietary intakes. PCR-RFLP and TAQMAN methodology were used to genotype PPARα Leu162Val, PPARγ Pro12Ala, PPARδ -87T>C, PPARGC1α Gly482Ser, FASN Val1483Ile and SREBF1 c.*619C>G. Statistical analyses were executed with SAS statistical package.

Results: Carriers of the Ala12 allele of PPARγ Pro12Ala polymorphism had higher intakes of total fat (p = 0.04). For FASN Val1483Ile polymorphism, significant gene-sex interaction effects were found for total fat and saturated fat intakes (p = 0.02 and p = 0.002, respectively). No significant difference in fat intakes was observed for PPARα Leu162Val, PPARδ -87T>C, PPARGC1α Gly482Ser and SREBF1 c.*619C>G polymorphisms.

Conclusions: Polymorphisms in PPARγ and FASN seem to be associated with dietary fat intakes. Genetic variants are important to take into account when studying dietary intakes.

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来源期刊

Journal of Nutrigenetics and Nutrigenomics GENETICS & HEREDITY-NUTRITION & DIETETICS

CiteScore

1.86

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The emerging field of nutrigenetics and nutrigenomics is rapidly gaining importance, and this new international journal has been established to meet the needs of the investigators for a high-quality platform for their research. Endorsed by the recently founded "International Society of Nutrigenetics/Nutrigenomics", the ‘Journal of Nutrigenetics and Nutrigenomics’ welcomes contributions not only investigating the role of genetic variation in response to diet and that of nutrients in the regulation of gene expression, but is also open for articles covering all aspects of gene-environment interactions in the determination of health and disease.