C标记氨基甲酸酯基的放射性合成及其在kappa -阿片受体示踪剂合成中的应用[j]。

Q2 Pharmacology, Toxicology and Pharmaceutics

Open Medicinal Chemistry Journal Pub Date : 2008-07-16 DOI:10.2174/1874104500802010072

B W Schoultz, E Arstad, J Marton, F Willoch, A Drzezga, H-J Wester, G Henriksen

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引用次数: 14

摘要

(11) c标记氨基甲酸酯可由伯胺或仲胺与CO(2)和(11)c -甲基化试剂进行三组分偶联反应得到。[(11)C]在温和条件下(温度下)，三氟化甲酯介导的氨基加合物甲基化以优异的收率提供了相应的(11)C标记氨基甲酸酯基团

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A New Method for Radiosynthesis of C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [C]GR103545.

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A New Method for Radiosynthesis of C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [C]GR103545.

(11)C-labeled carbamates can be obtained in a three-component coupling reaction of primary or secondary amines with CO(2) and (11)C-methylation reagents. [(11)C]Methyl-triflate mediated methylation of carbamino adducts provides the corresponding (11)C-labeled carbamate groups in excellent yields under mild conditions (temperatures

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来源期刊

Open Medicinal Chemistry Journal Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.40

自引率

0.00%

发文量