微波辅助合成氨基酸酯取代苯甲酸酰胺：人类 CD81-受体 HCV-E2 相互作用的潜在抑制剂。

Q2 Pharmacology, Toxicology and Pharmaceutics

Open Medicinal Chemistry Journal Pub Date : 2008-04-15 DOI:10.2174/1874104500802010021

Marcel Holzer, Sigrid Ziegler, Bernd Kronenberger, Christian D Klein, Rolf W Hartmann

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引用次数: 0

摘要

我们小组的研究结果表明，水杨酸苄酯是 CD81-LEL-HCV-E2 相互作用的中度抑制剂。为了提高生物活性，我们通过微波辅助 DCC 反应将杂环取代的苯甲酸与氨基酸酯偶联。利用 HUH7.5 细胞，通过荧光标记抗体检测系统测试了所制备化合物的抑制效力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction.

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Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction.

Results from our group showed benzyl salicylate to be a moderate inhibitor of the CD81-LEL-HCV-E2 interaction. To increase the biological activity, heterocyclic substituted benzoic acids were coupled to amino acid esters via microwave assisted DCC-reaction. The prepared compounds were tested for their inhibitory potency by means of a fluorescence labeled antibody assay system using HUH7.5 cells.

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来源期刊

Open Medicinal Chemistry Journal Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.40

自引率

0.00%

发文量