survivin δ -ex3亚型蛋白的分子对接与分析。

Q2 Pharmacology, Toxicology and Pharmaceutics

Open Medicinal Chemistry Journal Pub Date : 2008-03-27 DOI:10.2174/1874104500802010016

Z Ezziane

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引用次数: 4

摘要

该项目探索了Survivin-Delta-Ex3、H-Ras及其结合位点的分子模型，并生成了Delta-Ex3活性位点中XY2配体分子对接姿态和构象的能量优化三维坐标。目的是提出一种有效的抗癌药物，诱导细胞凋亡并抑制肿瘤血管生成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Molecular docking and analysis of survivin delta-ex3 isoform protein.

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Molecular docking and analysis of survivin delta-ex3 isoform protein.

This project explores molecular models of Survivin Delta-Ex3, H-Ras, and their binding sites, and generates energy optimized 3D coordinates of docked poses and conformations of the XY2 ligand molecule in the active site of Delta-Ex3. The aim is to propose an effective anti-cancer drug that induces apoptosis and inhibits tumor angiogenesis.

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来源期刊

Open Medicinal Chemistry Journal Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.40

自引率

0.00%

发文量