{"title":"中性粒细胞对环磷酰胺的反应预示着对与年龄相关的学习障碍的适应能力。","authors":"Katie Nickel, Marianne Bjorner, Warren Ladiges, Lida Zhu","doi":"10.31491/apt.2020.12.046","DOIUrl":null,"url":null,"abstract":"<p><p>The ability to respond to stress, defined as resilience, was measured by white blood cell counts in C57BL/6 mice of various ages receiving a nonlethal dose of cyclophosphamide (CYP). Neutrophil counts dipped and then rebounded in a consistent and age-dependent manner. Low neutrophil rebound correlated with improved learning in middle-age mice suggesting CYP-nduced neutrophil response may predict resilience to aging.</p>","PeriodicalId":7500,"journal":{"name":"Aging pathobiology and therapeutics","volume":" ","pages":"230-231"},"PeriodicalIF":0.0000,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789152/pdf/nihms-1754294.pdf","citationCount":"0","resultStr":"{\"title\":\"Neutrophil response to cyclophosphamide predicts resilience to age-related learning impairment.\",\"authors\":\"Katie Nickel, Marianne Bjorner, Warren Ladiges, Lida Zhu\",\"doi\":\"10.31491/apt.2020.12.046\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The ability to respond to stress, defined as resilience, was measured by white blood cell counts in C57BL/6 mice of various ages receiving a nonlethal dose of cyclophosphamide (CYP). Neutrophil counts dipped and then rebounded in a consistent and age-dependent manner. Low neutrophil rebound correlated with improved learning in middle-age mice suggesting CYP-nduced neutrophil response may predict resilience to aging.</p>\",\"PeriodicalId\":7500,\"journal\":{\"name\":\"Aging pathobiology and therapeutics\",\"volume\":\" \",\"pages\":\"230-231\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789152/pdf/nihms-1754294.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aging pathobiology and therapeutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31491/apt.2020.12.046\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging pathobiology and therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31491/apt.2020.12.046","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Neutrophil response to cyclophosphamide predicts resilience to age-related learning impairment.
The ability to respond to stress, defined as resilience, was measured by white blood cell counts in C57BL/6 mice of various ages receiving a nonlethal dose of cyclophosphamide (CYP). Neutrophil counts dipped and then rebounded in a consistent and age-dependent manner. Low neutrophil rebound correlated with improved learning in middle-age mice suggesting CYP-nduced neutrophil response may predict resilience to aging.
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