肿瘤坏死因子-α抑制剂阿达木单抗治疗囊性中性粒细胞肉芽肿性乳腺炎。

European journal of breast health Pub Date : 2021-12-30 eCollection Date: 2022-01-01 DOI:10.4274/ejbh.galenos.2021.2021-7-2
Le Wen Chiu, Karen Goodwin, Poonam Vohra, Erin Amerson
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引用次数: 4

摘要

特发性肉芽肿性乳腺炎(IGM)是一种罕见的良性炎性乳腺疾病,主要发生在产后5年内。囊性中性粒细胞肉芽肿性乳腺炎(CNGM)在临床上与IGM相同,但组织病理学显示明显的中心脂质空泡,由中性粒细胞包围,外带上皮样组织细胞/肉芽肿,空泡内不一致存在棒状细菌。对于IGM或CNGM的治疗尚无共识,可通过外科手术进行大面积局部切除或乳房切除术,或医学上使用抗生素、类固醇和保留类固醇的免疫抑制剂。我们报告了一名患有斑块型银屑病和CNGM的30岁女性患者,其乳房症状在使用肿瘤坏死因子α (TNF-α)抑制剂阿达木单抗治疗后得到缓解,这在以前没有被描述为CNGM的治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cystic Neutrophilic Granulomatous Mastitis Regression with the Tumor Necrosis Factor-α Inhibitor, Adalimumab.

Cystic Neutrophilic Granulomatous Mastitis Regression with the Tumor Necrosis Factor-α Inhibitor, Adalimumab.

Cystic Neutrophilic Granulomatous Mastitis Regression with the Tumor Necrosis Factor-α Inhibitor, Adalimumab.

Cystic Neutrophilic Granulomatous Mastitis Regression with the Tumor Necrosis Factor-α Inhibitor, Adalimumab.

Idiopathic granulomatous mastitis (IGM) is a rare, benign, inflammatory breast disease that primarily affects parous women within a period of five years post-partum. Cystic neutrophilic granulomatous mastitis (CNGM) is clinically identical to IGM, but histopathology demonstrates distinct central lipid vacuoles rimmed by neutrophils with an outer cuff of epithelioid histiocytes/granulomas, with inconsistent presence of Coryneform bacteria within the vacuoles. There is no consensus on the treatment for either IGM or CNGM, which may be managed surgically with wide local excision or mastectomy or medically with antibiotics, steroids, and steroid-sparing immunosuppressive agents. We present a 30-year-old woman with plaque psoriasis and CNGM whose breast symptoms resolved after treatment with the tumor necrosis factor alpha (TNF-α) inhibitor adalimumab, which has not previously been described as a treatment option for CNGM.

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