全基因组关联研究支持长非编码RNA LOC105372125的rs12966547变体与中国汉族女性精神分裂症和双相情感障碍的易感性显著相关。

IF 1.5 4区医学 Q4 GENETICS & HEREDITY

Psychiatric Genetics Pub Date : 2022-04-01 DOI:10.1097/YPG.0000000000000312

Zhi Zhao, Lulu Zhu, Xulong Wu, Qiang Chen, Bingyi Xu, Jialei Yang, Xiaojing Guo, Li Su

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引用次数: 1

摘要

目的：全基因组关联研究发现rs12966547多态性与欧洲人群精神分裂症易感性有关。最近的研究表明，精神分裂症和双相情感障碍可能存在基因重叠。在此，我们分析了中国汉族人群中LOC105372125rs12966547多态性与精神分裂症和双相情感障碍之间的关系。方法：我们的研究招募了548名精神分裂症患者、512名双相情感障碍患者和598名健康对照。使用Sequenom MassARRAY平台进行rs12966547的基因分型。结果：经性别和年龄校正后，rs12966547多态性与双相情感障碍易感性之间存在显著相关性（加性模型：Padj=0.040，隐性模型：Padj=0.044），rs12966547多态性与女性双相情感障碍（加性模型：Padj=0.027）和精神分裂症（显性模型：Padj=0.039）显著相关。rs12966547多态性与男性患双相情感障碍或精神分裂症的风险无显著相关性（Padj>0.05）。

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Genome-wide association studies-supported rs12966547 variant of the long noncoding RNA LOC105372125 is significantly associated with susceptibility to schizophrenia and bipolar disorder in Han Chinese women.

Objective: Genome-wide association studies have found that rs12966547 polymorphism was associated with susceptibility to schizophrenia in European populations. Recent studies showed that a genetic overlap may exist in schizophrenia and bipolar disorder. Here, we analyzed the associations between LOC105372125 rs12966547 polymorphism and schizophrenia and bipolar disorder in the Han Chinese population.

Methods: Our study recruited 548 schizophrenia patients, 512 bipolar disorder patients, and 598 healthy controls. Genotyping of rs12966547 were performed using the Sequenom MassARRAY platform.

Results: A significant association between rs12966547 polymorphism and susceptibility to bipolar disorder was observed after adjusting for sex and age (additive model: Padj = 0.040, recessive model: Padj = 0.044). However, no significant association was found between rs12966547 polymorphism and schizophrenia risk (all P > 0.05). In the analysis of gender, rs12966547 polymorphism was significantly associated with bipolar disorder (additive model: Padj = 0.027) and schizophrenia (dominant model: Padj = 0.039) in women. However, no significant association was found between rs12966547 polymorphism and the risk of bipolar disorder or schizophrenia in men (all Padj > 0.05).

Conclusions: Polymorphism of rs12966547 on the long noncoding RNA LOC10537215 are a shared genetic variant of schizophrenia and bipolar disorder in Han Chinese women.

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.