肿瘤微环境中髓源性抑制细胞的代谢重编程。

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Discovery medicine Pub Date : 2021-05-01

Liang Liu, Shuping Huo, Jianghui Liu, Qiaomin Li, Jing Wang

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引用次数: 0

摘要

近年来，人们对免疫细胞在抗肿瘤反应中的代谢进行了大量的研究。事实证明，代谢重编程可以决定免疫细胞的分化和功能。骨髓源性抑制细胞(MDSCs)是肿瘤微环境(TME)中异质的免疫抑制细胞群。它们能显著抑制T细胞的抗肿瘤反应，在促进肿瘤生长、转移和侵袭中发挥重要作用。本文综述了MDSCs在TME中的能量代谢途径，如脂肪酸氧化(FAO)、糖酵解和氨基酸(AAs)代谢，并强调了MDSCs的代谢重编程对其免疫抑制功能的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Metabolic Reprogramming of Myeloid-derived Suppressor Cells in the Tumor Microenvironment.

A large number of studies on the metabolism of immune cells in anti-tumor response have been carried out in recent years. It is proved that metabolic reprogramming can determine the differentiation and functions of immune cells. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immunosuppressive cells in the tumor microenvironment (TME). They can significantly inhibit the anti-tumor response of T cells and play an important role in promoting tumor growth, metastasis, and invasion. This review summarizes the energy metabolic pathways of MDSCs in the TME, such as fatty acid oxidation (FAO), glycolysis, and amino acids (AAs) metabolism, and highlights the importance of metabolic reprogramming of MDSCs for its immunosuppressive functions.

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来源期刊

Discovery medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Discovery Medicine publishes novel, provocative ideas and research findings that challenge conventional notions about disease mechanisms, diagnosis, treatment, or any of the life sciences subjects. It publishes cutting-edge, reliable, and authoritative information in all branches of life sciences but primarily in the following areas: Novel therapies and diagnostics (approved or experimental); innovative ideas, research technologies, and translational research that will give rise to the next generation of new drugs and therapies; breakthrough understanding of mechanism of disease, biology, and physiology; and commercialization of biomedical discoveries pertaining to the development of new drugs, therapies, medical devices, and research technology.