颞下颌关节退行性变的最新观点:来自下颌髁软骨细胞亚群的见解。

IF 2.5 3区 医学 Q3 CELL & TISSUE ENGINEERING
Stem cells and development Pub Date : 2022-08-01 Epub Date: 2022-02-18 DOI:10.1089/scd.2021.0324
Minglu Xu, Xuyang Zhang, Yao He
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引用次数: 1

摘要

颞下颌关节骨性关节炎(TMJOA)的高患病率导致关节功能障碍,表明需要更有效的治疗和修复方法。下颌髁突软骨(MCC)是TMJOA发展过程中发生退行性变化的典型纤维软骨,近年来已成为研究热点和治疗靶点。MCC由四个处于不同分化阶段的细胞区组成。MCC的细胞亚群在发育过程和TMJOA中表现出不同的生理病理特征。目前对TMJOA的研究主要集中在病理改变的基因调控上。相应的治疗靶点在MCC中具有特异性的细胞亚群,可能为软骨修复和TMJOA的治疗提供更准确可靠的结果。本文从MCC的发育和退化的角度,综述了目前MCC细胞亚群的研究进展。希望为进一步探讨TMJOA的病理过程及改善TMJOA的治疗提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Updated View on Temporomandibular Joint Degeneration: Insights from the Cell Subsets of Mandibular Condylar Cartilage.

The high prevalence of temporomandibular joint osteoarthritis (TMJOA), which causes joint dysfunction, indicates the need for more effective methods for treatment and repair. Mandibular condylar cartilage (MCC), a typical fibrocartilage that experiences degenerative changes during the development of TMJOA, has become a research focus and therapeutic target in recent years. MCC is composed of four zones of cells at various stages of differentiation. The cell subsets in MCC exhibit different physiological and pathological characteristics during development and in TMJOA. Most studies of TMJOA are mainly concerned with gene regulation of pathological changes. The corresponding treatment targets with specific cell subsets in MCC may provide more accurate and reliable results for cartilage repair and TMJOA treatment. In this review, we summarized the current research progress on the cell subsets of MCC from the perspective of MCC development and degeneration. We hope to provide a reference for further exploration of the pathological process of TMJOA and improvement of TMJOA treatment.

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来源期刊
Stem cells and development
Stem cells and development 医学-细胞与组织工程
CiteScore
7.80
自引率
2.50%
发文量
69
审稿时长
3 months
期刊介绍: Stem Cells and Development is globally recognized as the trusted source for critical, even controversial coverage of emerging hypotheses and novel findings. With a focus on stem cells of all tissue types and their potential therapeutic applications, the Journal provides clinical, basic, and translational scientists with cutting-edge research and findings. Stem Cells and Development coverage includes: Embryogenesis and adult counterparts of this process Physical processes linking stem cells, primary cell function, and structural development Hypotheses exploring the relationship between genotype and phenotype Development of vasculature, CNS, and other germ layer development and defects Pluripotentiality of embryonic and somatic stem cells The role of genetic and epigenetic factors in development
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