喉癌肿瘤浸润CD8+ t细胞与PD-L1表达的相关性及其预后意义:前瞻性非介入性试验

Q3 Medicine
The gulf journal of oncology Pub Date : 2021-09-01
Maha Ismail, Marwa M Shakweer, Hesham ElWakiel, Dalia Abd El Ghany, Ahmed Gaballah
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引用次数: 0

摘要

肿瘤微环境在肿瘤进化过程中起着至关重要的作用。免疫细胞与癌细胞的抵抗之间存在着动态的、持续的关系。肿瘤浸润cd8 -淋巴细胞和程序性死亡配体-1在不同恶性肿瘤中具有重要的预后作用。我们的目的是评估其在喉癌中的作用。患者和方法:我们前瞻性分析喉癌患者标本,鉴定cd8淋巴细胞和PD-L1的表达。PD-L1的百分比和强度之和构成总分。当综合百分比和强度得分为0到4分时,最终比率被认为是负或低,当得分为5到7分时,最终比率被认为是高。cd8淋巴细胞浸润分为强浸润(上皮细胞= 10/100或基质细胞=20/100)和弱浸润(结果:共纳入40例患者;12例为1期或2期,28例为晚期。92.5%的患者PD-L1表达阳性。PD-L1和CD8-淋巴细胞对总生存率均无影响,但在晚期亚组中,高PD-L1与较好的生存率相关(p = 0.036),高CD8-淋巴细胞浸润对生存率有较好的影响,但未达到显著性意义。与cd8淋巴细胞浸润有显著相关性;无论是上皮还是间质,以及肿瘤PD-L1的表达;p值分别为0.001和< 0.0001。低CD8+浸润和低PD-L1患者亚组生存率最差。结论:喉癌CD8- 1淋巴细胞浸润与PD-L1表达存在相关性,PD-L1高表达与喉癌晚期生存率较高相关。关键词:PD-L1, CD8,喉癌,肿瘤微环境
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation Between Tumor Infiltration CD8+ T-cells And PD-L1 Expression In Laryngeal Cancer And Their Prognostic Significance: Prospective Non-interventional Trial.

Introduction: Tumor microenvironment plays crucial role in cancer evolution. There is a dynamic and continuous relation between immune cells and cancer cells' resistance. Tumor infiltration CD8-lymphocytes and programmed death ligand-1 have proved important prognostic role in different malignancies. We aimed at evaluating this role in laryngeal cancer.

Patients and methods: We prospectively analyzed laryngeal cancer patients' specimens, to identify the CD8-lymphocytes and the PD-L1 expression. A total score formed of the sum of percentage and intensity of PD-L1. A final rate was considered as negative or low when combined percentage and intensity scores 0 to 4, and high when scores 5-7. CD8-lymphocyte infiltration was divided into strong (= 10/100 of epithelial cells or =20/100 stromal cell infiltration) or weak (<10/100 epithelial cells or <20/100 stromal cell infiltration).

Results: Forty patients were included; twelve had stage 1 or 2 and 28 with advanced stages. PD-L1 expressionwas positive in 92.5%. Neither the PD-L1 nor CD8- lymphocytes had overall survival impact, however high PD-L1 correlated with better survival in advanced stage subgroup (p = 0.036), high CD8-lymphocytes infiltration had better survival but did not reach significance. Therewas significant correlation between the CD8-lymphocyte infiltration; whether epithelial or stromal, and tumor PD-L1 expression; p-value of 0.001 and < 0.0001 respectively. Subgroup of patients with low CD8+ infiltration and low PD-L1 had the worst survival.

Conclusion: There is a correlation between CD8- l lymphocytes infiltration and PD-L1 expression inlaryngeal cancer and high PD-L1 expression is associated with better OS in advanced stages. Key words: PD-L1, CD8, laryngeal cancer, tumor microenvironment.

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来源期刊
The gulf journal of oncology
The gulf journal of oncology Medicine-Medicine (all)
CiteScore
0.90
自引率
0.00%
发文量
37
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