S Afrashteh, M Fararouei, M T Parad, A Mirahmadizadeh
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引用次数: 3
摘要
背景:压力和睡眠障碍已被发现与许多不良健康结果相关，包括癌症。我们的研究旨在衡量睡眠质量、脾气暴躁和生活压力与甲状腺癌风险之间的关系。方法:对361例新诊断的TC患者和347例性别年龄频率匹配的对照组进行研究。对照组和病例参与者在同一健康中心登记。我们使用多元逻辑回归来调查TC风险与相关因素之间的关系。结果:多因素分析结果显示，压力(或总是紧张/经常冷静= 3.07,95% CI 1.42 ~ 6.63)和脾气暴躁(或紧张/冷静= 2.00,95% CI 1.28 ~ 3.11)与TC风险直接相关。另一方面，高质量的睡眠(or有时/从不= 0.36,95% CI 0.16-0.79)和高质量的睡眠(or经常/不= 0.45,95% CI 0.21-0.96, P = 0.041)似乎是一个保护因素。结论:一些基于社区的干预措施，如降低压力水平和改善睡眠质量，可能有助于预防不同类型的癌症，包括TC。我们建议进一步评估这些在预防TC癌方面的重要发现。
Sleep quality, stress and thyroid cancer: a case-control study.
Background: Stress and sleep disturbance have been found to be associated with numerous adverse health outcomes, including cancer. Our study aimed to measure the association between quality of sleep, short-temperedness, and stress in life with the risk of thyroid cancer.
Methods: The present study is conducted on 361 newly diagnosed TC patients and 347 sex-age frequency matched controls. Control and case participants were registered with the same health centers. We used multiple logistic regression to investigate the association between TC risk and the interested factors.
Results: Based on the results of the multivariate analysis, stress (ORalways stressful/often calm = 3.07, 95% CI 1.42-6.63) and short-temperedness (ORnervous/calm = 2.00, 95% CI 1.28-3.11) were directly associated with the risk of TC. On the other hand having a quality sleep (ORsometimes/never = 0.36, 95% CI 0.16-0.79) and quality sleep (ORoften/no = 0.45, 95% CI 0.21-0.96, P = 0.041) seems to be a protective factor.
Conclusions: Some community-based interventions, e.g., lowering stress levels and improving sleep quality, may help in preventing different types of cancer, including TC. We suggest further evaluation of these important findings in the prevention of TC cancer.
期刊介绍：
The Journal of Endocrinological Investigation is a well-established, e-only endocrine journal founded 36 years ago in 1978. It is the official journal of the Italian Society of Endocrinology (SIE), established in 1964. Other Italian societies in the endocrinology and metabolism field are affiliated to the journal: Italian Society of Andrology and Sexual Medicine, Italian Society of Obesity, Italian Society of Pediatric Endocrinology and Diabetology, Clinical Endocrinologists’ Association, Thyroid Association, Endocrine Surgical Units Association, Italian Society of Pharmacology.
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