微创细胞治疗膝症状性骨髓病变:一项1年的前瞻性临床研究

IF 2.5 3区 医学 Q3 CELL & TISSUE ENGINEERING
Stem cells and development Pub Date : 2022-08-01 Epub Date: 2022-02-18 DOI:10.1089/scd.2021.0283
Ignacio Dallo, Riccardo D'Ambrosi, Dawid Szwedowski, Ali Mobasheri, Alberto Gobbi
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引用次数: 1

摘要

骨髓损伤(BMLs)是磁共振成像的典型表现,存在于不同的病理中,如自发性不全骨折、骨坏死、短暂性骨髓损伤综合征、骨关节炎和创伤。多种情况下BMLs的病因和演变尚不清楚。目前还没有治疗膝关节症状性脑损伤的金标准方案。骨芯成形术(Osteo Core Plasty™)的生物增强是一种新的治疗方式,显示出有希望的减轻疼痛的效果,目的是阻止疾病的进展。本前瞻性研究的目的是报告骨芯成形术治疗膝关节症状性脑损伤的临床结果和安全性。本研究纳入了15例经骨核成形术治疗的症状性膝骨髓瘤患者,并对其进行了至少12个月的前瞻性随访。术前、术后6个月和12个月分别采用Tegner评分、Marx评分、国际膝关节文献委员会、膝关节损伤和骨关节炎结局评分(疼痛、日常生活活动和生活质量亚量表)以及疼痛视觉模拟量表对每位患者进行评估。在整个随访过程中,除Tegner和Marx评分外,所有临床评分均有统计学上的显著改善(P P 0 vs. T1;T0 vs. T2;T1 vs. T2)。无并发症报道。这些初步结果证实,在1年的随访中,骨核成形术的生物软骨下骨增强技术是一种安全有效的微创治疗膝关节症状性脑损伤的选择。未来仍需要进行高质量的随机对照试验研究和系统评价,以进一步加强预防或治疗膝关节骨髓瘤的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Minimally Invasive Cell-Based Therapy for Symptomatic Bone Marrow Lesions of the Knee: A Prospective Clinical Study at 1 Year.

Bone marrow lesions (BMLs) are typical findings in magnetic resonance imaging present in different pathologies, such as spontaneous insufficiency fractures, osteonecrosis, transient BML syndromes, osteoarthritis, and trauma. The etiology and evolution of BMLs in multiple conditions remain unclear. There is still no gold standard protocol for the treatment of symptomatic BMLs in the knee. The biologic augmentation by Osteo Core Plasty™ is a new treatment modality showing promising results reducing pain with the aim to stop the progression of the disease. The purpose of this prospective study is to report the clinical outcomes and safety of Osteo Core Plasty for the treatment of symptomatic BMLs in the knee. Fifteen patients with symptomatic BMLs of the knee treated with the Osteo Core Plasty technique were included and followed prospectively for a minimum of 12 months. Each patient was evaluated before the surgery and respectively at 6 and 12 months using the Tegner Score, Marx Score, the International Knee Documentation Committee, the Knee Injury and Osteoarthritis Outcome Score divided in pain, activity daily living and quality of life subscale, and the Visual Analog Scale for pain. All clinical scores except Tegner and Marx score showed an overall statistically significant improvement through the entire follow-up (P < 0.05) and a significant improvement (P < 0.05) between each follow-up period (T0 vs. T1; T0 vs. T2; T1 vs. T2). No complications were reported. These preliminary results confirm that biological subchondral bone augmentation by Osteo Core Plasty technique is a safe and effective minimally invasive treatment option for symptomatic BMLs in the knee at 1-year follow-up. There is still a need for high-quality randomized controlled trials studies and systematic reviews in the future to enhance further treatment strategies in preventing or treating BMLs of the knee.

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来源期刊
Stem cells and development
Stem cells and development 医学-细胞与组织工程
CiteScore
7.80
自引率
2.50%
发文量
69
审稿时长
3 months
期刊介绍: Stem Cells and Development is globally recognized as the trusted source for critical, even controversial coverage of emerging hypotheses and novel findings. With a focus on stem cells of all tissue types and their potential therapeutic applications, the Journal provides clinical, basic, and translational scientists with cutting-edge research and findings. Stem Cells and Development coverage includes: Embryogenesis and adult counterparts of this process Physical processes linking stem cells, primary cell function, and structural development Hypotheses exploring the relationship between genotype and phenotype Development of vasculature, CNS, and other germ layer development and defects Pluripotentiality of embryonic and somatic stem cells The role of genetic and epigenetic factors in development
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