脂多糖结合蛋白作为结直肠癌患者术后感染和炎症并发症发生的危险因素

Pub Date : 2021-01-01 Epub Date: 2021-10-14 DOI:10.5114/wo.2021.110051
Yermek Turgunov, Alina Ogizbayeva, Lyudmila Akhmaltdinova, Kayrat Shakeyev
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引用次数: 1

摘要

研究目的:在这项试点研究中,脂多糖结合蛋白(LBP)水平被评估为结直肠癌(CRC)术后发生全身炎症反应综合征(SIRS)以及感染和炎症并发症的可能危险因素。材料与方法:术前1 h、术后72 h分别取静脉血测定腰压。所有患者根据是否存在急性肠梗阻(ABO)、SIRS和并发症进行分层。结果:36例结直肠癌患者参与研究。术前LBP水平879.8±221.8 ng/ml(四分位数间距(IQR) 749.3 ~ 1028.8);第3天为766.5±159.4 ng/ml (IQR 669.5 ~ 847.6),差异有统计学意义(p = 0.004)。LBP水平下降超过280 ng/ml会增加手术结直肠癌患者SIRS和并发症的可能性(OR分别为6.6,95% CI: 1.1-40.9和OR为12.0,95% CI: 1.8-80.4)。有SIRS的ABO患者LBP值下降幅度大于无SIRS的患者(p = 0.046)。结论:本研究表明,结直肠癌术后患者LBP水平在术后第3天呈下降趋势。LBP水平下降幅度越大,发生SIRS和术后感染及炎症并发症的可能性就越大。因此,需要更多患者的进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lipopolysaccharide-binding protein as a risk factor for development of infectious and inflammatory postsurgical complications in colorectal cancer paients.

Aim of the study: In this pilot study lipopolysaccharide-binding protein (LBP) levels were assessed as a possible risk factor for development of systemic inflammatory response syndrome (SIRS) and infectious and inflammatory complications in colorectal cancer (CRC) patients after surgery.

Material and methods: For LBP determination venous blood was taken 1 hour before the surgery and 72 hours after it. All patients were stratified by the presence or absence of acute bowel obstruction (ABO), SIRS and complications.

Results: 36 patients with CRC participated in the study. The LBP level before surgery was 879.8 ± 221.8 ng/ml (interquartile range (IQR) 749.3-1028.8); on the 3rd day it was 766.5 ± 159.4 ng/ml (IQR 669.5-847.6), which was a statistically significant decrease (p = 0.004). A decrease in LBP level by more than 280 ng/ml increases the probability of SIRS and complications in operated CRC patients (OR 6.6, 95% CI: 1.1-40.9 and OR 12.0, 95% CI: 1.8-80.4, respectively). In patients with ABO in the presence of SIRS, the LBP value decreased more than in those without SIRS (p = 0.046).

Conclusions: This study demonstrated that the LBP level in the operated CRC patients tends to decrease on the 3rd day after surgery. A bigger decrease in LBP level increases the probability of SIRS and postoperative infectious and inflammatory complications. Therefore, further studies with larger numbers of patients are required.

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