建设印度生物铸造厂:挑战和前进道路。

IF 2.6 Q2 BIOCHEMICAL RESEARCH METHODS
Synthetic biology (Oxford, England) Pub Date : 2021-06-25 eCollection Date: 2021-01-01 DOI:10.1093/synbio/ysab015
Binay Panda, Pawan K Dhar
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引用次数: 1

摘要

生物铸造厂是生物制造与自动化相结合的地方。生物铸造厂的高度模块化结构有助于加快设计-构建-测试-学习的工作流程,以快速且流线型的方式交付产品。从这个角度来看,我们描述了我们为建立印度生物铸造厂所做的努力,我们认为该设施在支持研究、创新和创业方面增加了巨大的价值。我们描述了我们关注的三个关键领域,利用测序基因组非表达部分的潜力,在途径重建和合成酶和代谢物中使用深度学习。最后,我们描述了在印度建立这样的设施所面临的具体挑战,以及缓解与世界其他生物代工厂合作所面临的一些挑战的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Building Biofoundry India: challenges and path forward.

Building Biofoundry India: challenges and path forward.

Building Biofoundry India: challenges and path forward.

Biofoundry is a place where biomanufacturing meets automation. The highly modular structure of a biofoundry helps accelerate the design-build-test-learn workflow to deliver products fast and in a streamlined fashion. In this perspective, we describe our efforts to build Biofoundry India, where we see the facility add a substantial value in supporting research, innovation and entrepreneurship. We describe three key areas of our focus, harnessing the potential of non-expressing parts of the sequenced genomes, using deep learning in pathway reconstruction and synthesising enzymes and metabolites. Toward the end, we describe specific challenges in building such facility in India and the path to mitigate some of those working with the other biofoundries worldwide.

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