Titilope Olanipekun, Temidayo Ayotomiwa Abe, Valery Sammah Effoe, Joffi E Musonge-Effoe, Agusiegbe Chuks, Esther Kwara, Alexandra Caldwell, Samed Obeng, Nicolas Bakinde, Gloria Westney, Richard Snyder
{"title":"格鲁吉亚夏季和秋季重症COVID-19患者的重症监护病房住院情况和结果激增。","authors":"Titilope Olanipekun, Temidayo Ayotomiwa Abe, Valery Sammah Effoe, Joffi E Musonge-Effoe, Agusiegbe Chuks, Esther Kwara, Alexandra Caldwell, Samed Obeng, Nicolas Bakinde, Gloria Westney, Richard Snyder","doi":"10.5492/wjccm.v10.i6.369","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is limited data on the difference in the clinical characteristics and outcomes of patients with severe coronavirus disease 2019 (COVID-19) infection in the summer compared to the fall surge.</p><p><strong>Aim: </strong>To compare the sociodemographic, clinical characteristics, and outcomes among mechanically ventilated patients with severe COVID-19 infection admitted to the intensive care unit (ICU) during the summer and fall surges in the year 2020.</p><p><strong>Methods: </strong>We included patients admitted to the ICU and treated with invasive mechanical ventilation for COVID-19 associated respiratory failure between April 1 and December 31, 2020. Patients were categorized into summer surge for ICU admissions between June 15, 2020, and August 15, 2020, and fall surge between October 15, 2020, and December 31, 2020. We compared patients' characteristics and outcomes using descriptive and inferential statistics.</p><p><strong>Results: </strong>A total of 220 patients were admitted to the Grady Memorial Hospital ICU and mechanically ventilated for COVID-19 associated hypoxemic respiratory failure during the period considered (125 during the summer surge and 95 during the fall surge). More women were admitted in the fall compared to summer (41.1% <i>vs</i> 36.8%, difference, 4.3%; 95%CI: 1.2, 7.5). Patients admitted in the fall had fewer comorbidities (chronic obstructive pulmonary disease, stroke, diabetes mellitus, obstructive sleep apnea and body mass index ≥ 35 kg/m<sup>2</sup>). Overall, patients in the fall had a lower ICU mortality rate (27.4% <i>vs</i> 38.4%, difference, -11.0; 95%CI: -6.4, -18.2), shorter length of stay on the mechanical ventilator (7 d <i>vs</i> 11 d, difference, 4 d; 95%CI: 2.1, 6.6) and shorter ICU length of stay (9 d <i>vs</i> 14 d, difference, 5 d; 95%CI: 2.7, 9.4).</p><p><strong>Conclusion: </strong>Patients admitted with severe COVID-19 infection requiring mechanical ventilation had better outcomes in the fall than summer. This difference observed is likely attributable to a better understanding of the condition and advances in treatment strategies.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/af/WJCCM-10-369.PMC8613716.pdf","citationCount":"2","resultStr":"{\"title\":\"Intensive care unit hospitalizations and outcomes in patients with severe COVID-19 during summer and fall surges in Georgia.\",\"authors\":\"Titilope Olanipekun, Temidayo Ayotomiwa Abe, Valery Sammah Effoe, Joffi E Musonge-Effoe, Agusiegbe Chuks, Esther Kwara, Alexandra Caldwell, Samed Obeng, Nicolas Bakinde, Gloria Westney, Richard Snyder\",\"doi\":\"10.5492/wjccm.v10.i6.369\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There is limited data on the difference in the clinical characteristics and outcomes of patients with severe coronavirus disease 2019 (COVID-19) infection in the summer compared to the fall surge.</p><p><strong>Aim: </strong>To compare the sociodemographic, clinical characteristics, and outcomes among mechanically ventilated patients with severe COVID-19 infection admitted to the intensive care unit (ICU) during the summer and fall surges in the year 2020.</p><p><strong>Methods: </strong>We included patients admitted to the ICU and treated with invasive mechanical ventilation for COVID-19 associated respiratory failure between April 1 and December 31, 2020. Patients were categorized into summer surge for ICU admissions between June 15, 2020, and August 15, 2020, and fall surge between October 15, 2020, and December 31, 2020. We compared patients' characteristics and outcomes using descriptive and inferential statistics.</p><p><strong>Results: </strong>A total of 220 patients were admitted to the Grady Memorial Hospital ICU and mechanically ventilated for COVID-19 associated hypoxemic respiratory failure during the period considered (125 during the summer surge and 95 during the fall surge). More women were admitted in the fall compared to summer (41.1% <i>vs</i> 36.8%, difference, 4.3%; 95%CI: 1.2, 7.5). Patients admitted in the fall had fewer comorbidities (chronic obstructive pulmonary disease, stroke, diabetes mellitus, obstructive sleep apnea and body mass index ≥ 35 kg/m<sup>2</sup>). Overall, patients in the fall had a lower ICU mortality rate (27.4% <i>vs</i> 38.4%, difference, -11.0; 95%CI: -6.4, -18.2), shorter length of stay on the mechanical ventilator (7 d <i>vs</i> 11 d, difference, 4 d; 95%CI: 2.1, 6.6) and shorter ICU length of stay (9 d <i>vs</i> 14 d, difference, 5 d; 95%CI: 2.7, 9.4).</p><p><strong>Conclusion: </strong>Patients admitted with severe COVID-19 infection requiring mechanical ventilation had better outcomes in the fall than summer. This difference observed is likely attributable to a better understanding of the condition and advances in treatment strategies.</p>\",\"PeriodicalId\":66959,\"journal\":{\"name\":\"世界危重病急救学杂志(英文版)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-11-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/af/WJCCM-10-369.PMC8613716.pdf\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"世界危重病急救学杂志(英文版)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5492/wjccm.v10.i6.369\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"世界危重病急救学杂志(英文版)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5492/wjccm.v10.i6.369","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
摘要
背景:目前关于2019年严重冠状病毒病(COVID-19)夏季感染患者的临床特征和结局与秋季感染患者的差异的数据有限。目的:比较2020年夏秋两季重症监护病房(ICU)重症肺炎(COVID-19)机械通气患者的社会人口学、临床特征及转诊结果。方法:纳入2020年4月1日至12月31日期间因COVID-19相关呼吸衰竭入住ICU并接受有创机械通气治疗的患者。将患者分为2020年6月15日至2020年8月15日的夏季ICU入院高峰和2020年10月15日至2020年12月31日的秋季高峰。我们使用描述性和推断性统计比较了患者的特征和结果。结果:在研究期间，共有220例患者因COVID-19相关低氧性呼吸衰竭入住Grady Memorial Hospital ICU并进行机械通气(夏季高峰125例，秋季高峰95例)。与夏季相比，秋季录取的女性更多(41.1%比36.8%，差4.3%);95%ci: 1.2, 7.5)。秋季入院的患者合并症(慢性阻塞性肺疾病、中风、糖尿病、阻塞性睡眠呼吸暂停和体重指数≥35 kg/m2)较少。总体而言，秋季患者的ICU死亡率较低(27.4% vs 38.4%，差值为-11.0;95%CI: -6.4， -18.2)，机械呼吸机停留时间较短(7天vs 11天，差4天;95%CI: 2.1, 6.6)和更短的ICU住院时间(9天vs 14天，差5天;95%ci: 2.7, 9.4)。结论:重症COVID-19感染需机械通气患者秋季预后优于夏季。观察到的这种差异可能归因于对病情的更好理解和治疗策略的进步。
Intensive care unit hospitalizations and outcomes in patients with severe COVID-19 during summer and fall surges in Georgia.
Background: There is limited data on the difference in the clinical characteristics and outcomes of patients with severe coronavirus disease 2019 (COVID-19) infection in the summer compared to the fall surge.
Aim: To compare the sociodemographic, clinical characteristics, and outcomes among mechanically ventilated patients with severe COVID-19 infection admitted to the intensive care unit (ICU) during the summer and fall surges in the year 2020.
Methods: We included patients admitted to the ICU and treated with invasive mechanical ventilation for COVID-19 associated respiratory failure between April 1 and December 31, 2020. Patients were categorized into summer surge for ICU admissions between June 15, 2020, and August 15, 2020, and fall surge between October 15, 2020, and December 31, 2020. We compared patients' characteristics and outcomes using descriptive and inferential statistics.
Results: A total of 220 patients were admitted to the Grady Memorial Hospital ICU and mechanically ventilated for COVID-19 associated hypoxemic respiratory failure during the period considered (125 during the summer surge and 95 during the fall surge). More women were admitted in the fall compared to summer (41.1% vs 36.8%, difference, 4.3%; 95%CI: 1.2, 7.5). Patients admitted in the fall had fewer comorbidities (chronic obstructive pulmonary disease, stroke, diabetes mellitus, obstructive sleep apnea and body mass index ≥ 35 kg/m2). Overall, patients in the fall had a lower ICU mortality rate (27.4% vs 38.4%, difference, -11.0; 95%CI: -6.4, -18.2), shorter length of stay on the mechanical ventilator (7 d vs 11 d, difference, 4 d; 95%CI: 2.1, 6.6) and shorter ICU length of stay (9 d vs 14 d, difference, 5 d; 95%CI: 2.7, 9.4).
Conclusion: Patients admitted with severe COVID-19 infection requiring mechanical ventilation had better outcomes in the fall than summer. This difference observed is likely attributable to a better understanding of the condition and advances in treatment strategies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
