一项评估标准化教育计划对中重度牛皮癣患者生活质量、疾病严重程度和疾病知识影响的多中心随机对照研究:EDUPSO研究

Dermatology (Basel, Switzerland) Pub Date : 2022-01-01 Epub Date: 2021-12-09 DOI:10.1159/000520289
Fatma Jendoubi, Stefana Balica, Marie Aleth Richard, Christine Chiaverini, Claire Bernier, Nathalie Quiles, Herve Bachelez, Marie Beylot-Barry, Stéphanie Mallet, Catherine Goujon, Josiane Parier, Laurent Misery, Florence Carrere, Valérie Lauwers-Cances, Carle Paul
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引用次数: 3

摘要

背景:银屑病是一种慢性炎症性皮肤病,对健康相关生活质量(HRQoL)有着深远的影响。患者教育计划可以帮助患者获得对慢性疾病的终生控制。目的:本多中心随机对照研究评估标准化多学科教育计划对牛皮癣患者是否有益。方法:将患有中重度牛皮癣的成年人按1:1的比例随机分为干预组接受教育计划,对照组接受常规护理。根据既往治疗史进行随机分层。主要结果是HRQoL,通过对Skindex-29领域的情绪、症状和功能进行评分来评估。银屑病严重程度采用银屑病区域严重程度指数(PASI)进行评估。感知压力水平、患者对牛皮癣的了解程度和患者满意度也被评估。随访3、6、12个月。结果:142例患者形成意向治疗人群,对照组70例,干预组72例。与基线相比,两组在3、6和12个月时皮肤指数成分评分和PASI均显著降低,但两组之间无显著差异。与对照组相比,干预组患者在随访期间对牛皮癣的认识有了显著提高(68%对56%;P < 0.01)。干预组患者对银屑病管理和治疗的满意度也较高。结论:标准化教育方案并没有改善银屑病患者的HRQoL和病情严重程度,但显著提高了患者对银屑病的认识,提高了患者的满意度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Multicentre Randomised Controlled Study Evaluating the Effect of a Standardised Education Programme on Quality of Life, Disease Severity, and Disease Knowledge in Patients with Moderate-To-Severe Psoriasis: The EDUPSO Study.

Background: Psoriasis is a chronic inflammatory skin disease that has a profound effect on health-related quality of life (HRQoL). Patient education programmes may help patients to gain life-long control over their chronic disease.

Objective: This multicentre randomised controlled study evaluated whether a standardised multidisciplinary education programme was beneficial to psoriasis patients.

Methods: Adults with moderate-to-severe psoriasis were randomly assigned (1:1) to an intervention group to receive an educational programme or to a control group to receive usual care. Randomization was stratified by previous treatment history. The primary outcome was HRQoL, assessed by scoring the Skindex-29 domains emotion, symptom, and functioning. Psoriasis severity was assessed using the psoriasis area severity index (PASI). Levels of perceived stress, patient knowledge about psoriasis, and patient satisfaction were also assessed. Follow-up evaluations were performed at 3, 6, and 12 months.

Results: A total 142 patients formed the intention-to-treat population: 70 in the control group and 72 in the intervention group. Skindex component scores and the PASI were significantly lower at 3, 6, and 12 months as compared to baseline in both groups, but no significant differences were found between the groups. Knowledge about psoriasis improved significantly during follow-up amongst patients from the intervention group compared to controls (68% of correct answers vs. 56%; p < 0.01). Patient satisfaction with psoriasis management and treatment was also better in the intervention group.

Conclusions: The standardised education programme did not improve HRQoL and disease severity in psoriasis, but led to a significant improvement in patient knowledge about the disease and increased patient satisfaction.

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