胃腺癌中HER2的研究进展如何?

IF 1.7 4区医学 Q3 PHARMACOLOGY & PHARMACY

Personalized medicine Pub Date : 2022-01-01 Epub Date: 2021-12-09 DOI:10.2217/pme-2021-0004

Khalil El Gharib, Makram Khoury, Hampig Raphael Kourie

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引用次数: 1

摘要

目的:HER2是在10-30%的胃腺癌中表达的原癌基因，是抑制高复发率和低生存率的恶性肿瘤的理想靶点。材料与方法:通过PubMed、Google Scholar和clinicaltrials.gov数据库进行系统搜索，报告正在进行和过去研究胃癌中HER2抑制剂的结果。结果:纳入25项研究;ToGA试验是批准在转移性胃癌中使用曲妥珠单抗的关键试验，随后还有更多研究在这种情况下调查其他HER2抑制剂，以及局部和局部区域恶性肿瘤。结论:抗her2分子治疗胃癌具有良好的疗效和安全性;证据越来越多，与其他癌症制剂的关联正在调查中。

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HER2 in gastric adenocarcinoma: where do we stand today?

Aim:HER2 is a proto-oncogene expressed in 10-30% of gastric adenocarcinomas and is an ideal target for inhibition in malignancy with high recurrence and dismal survival rates. Materials & methods: A systematic search was conducted via PubMed, Google Scholar and the clinicaltrials.gov database to report the results of ongoing and past studies investigating HER2 inhibitors in gastric cancer. Results: Twenty-five studies were included; ToGA trial is the pivotal trial approving the use of trastuzumab in metastatic gastric cancer, followed by more studies investigating other HER2 inhibitors in this setting, as well as in local and locoregional malignancy. Conclusion: Anti-HER2 molecules are proving efficacy and safety in gastric cancer; the evidence is growing and association with other cancer agents is under investigation.

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来源期刊

Personalized medicine 医学-药学

CiteScore

3.30

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Personalized Medicine (ISSN 1741-0541) translates recent genomic, genetic and proteomic advances into the clinical context. The journal provides an integrated forum for all players involved - academic and clinical researchers, pharmaceutical companies, regulatory authorities, healthcare management organizations, patient organizations and others in the healthcare community. Personalized Medicine assists these parties to shape thefuture of medicine by providing a platform for expert commentary and analysis. The journal addresses scientific, commercial and policy issues in the field of precision medicine and includes news and views, current awareness regarding new biomarkers, concise commentary and analysis, reports from the conference circuit and full review articles.