Charmaine A Cabiscuelas, Lan Ying Li, Ki Eun Seon, Yup Kim, Jae Hoon Lee, Eun Ji Nam, Jung-Yun Lee, Sunghoon Kim, Young Tae Kim, Sang Wun Kim
{"title":"单孔腹腔镜子宫内膜异位症与非子宫内膜异位症卵巢囊肿去核患者血清抗苗勒管激素水平变化的比较。","authors":"Charmaine A Cabiscuelas, Lan Ying Li, Ki Eun Seon, Yup Kim, Jae Hoon Lee, Eun Ji Nam, Jung-Yun Lee, Sunghoon Kim, Young Tae Kim, Sang Wun Kim","doi":"10.6118/jmm.21031","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study compared serum anti-Mullerian hormone (AMH) levels in endometriotic cysts (ECs) with those in non-ECs and analyzed changes thereof after single-port laparoscopic (SPL) ovarian cyst enucleation using vasopressin injection.</p><p><strong>Methods: </strong>In total, 180 patients (EC group, n = 112; non-EC group, n = 68) who underwent SPL ovarian cyst enucleation were retrospectively reviewed. Their AMH levels were checked preoperatively, on postoperative day 10 (POD10), and on postoperative month 3 (POM3). Changes in AMH levels were analyzed according to tumor type and vasopressin use.</p><p><strong>Results: </strong>The median initial and postoperative serum AMH levels in the EC group were significantly lower than those in the non-EC group (preoperation: 2.0 vs 3.8 ng/mL, <i>P</i> < 0.001; POD10: 1.0 vs 3.2 ng/mL, <i>P</i> < 0.001; POM3: 1.2 vs 3.6 ng/mL, <i>P</i> < 0.001). The postoperative decrease in AMH levels was higher in the EC group than the non-EC group on POD10 (0.8 vs 0.5 ng/mL, <i>P</i> = 0.011) but not on POM3 (0.7 vs 0.5 ng/mL, <i>P</i> = 0.164). Vasopressin injection during EC enucleation had no significant effect on the decrease in AMH levels on POD10 (vasopressin group vs non-vasopressin group: 1.0 vs 0.8 ng/mL, <i>P</i> = 0.253) and POM3 (vasopressin group vs nonvasopressin group: 1.4 vs 1.1 ng/mL, <i>P</i> = 0.242).</p><p><strong>Conclusions: </strong>AMH levels were lower at baseline and had higher decreasing rates after SPL surgery in the EC group relative to the non-EC group. Vasopressin injection might not protect the ovary from the postoperative decrease in AMH levels.</p>","PeriodicalId":16410,"journal":{"name":"Journal of Menopausal Medicine","volume":"27 3","pages":"168-174"},"PeriodicalIF":0.0000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/5e/jmm-27-168.PMC8738850.pdf","citationCount":"1","resultStr":"{\"title\":\"Comparison of Serum Anti-Mullerian Hormone-Level Changes in Single-Port Laparoscopic Endometriotic and Non-Endometriotic Ovarian Cyst Enucleations.\",\"authors\":\"Charmaine A Cabiscuelas, Lan Ying Li, Ki Eun Seon, Yup Kim, Jae Hoon Lee, Eun Ji Nam, Jung-Yun Lee, Sunghoon Kim, Young Tae Kim, Sang Wun Kim\",\"doi\":\"10.6118/jmm.21031\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study compared serum anti-Mullerian hormone (AMH) levels in endometriotic cysts (ECs) with those in non-ECs and analyzed changes thereof after single-port laparoscopic (SPL) ovarian cyst enucleation using vasopressin injection.</p><p><strong>Methods: </strong>In total, 180 patients (EC group, n = 112; non-EC group, n = 68) who underwent SPL ovarian cyst enucleation were retrospectively reviewed. Their AMH levels were checked preoperatively, on postoperative day 10 (POD10), and on postoperative month 3 (POM3). Changes in AMH levels were analyzed according to tumor type and vasopressin use.</p><p><strong>Results: </strong>The median initial and postoperative serum AMH levels in the EC group were significantly lower than those in the non-EC group (preoperation: 2.0 vs 3.8 ng/mL, <i>P</i> < 0.001; POD10: 1.0 vs 3.2 ng/mL, <i>P</i> < 0.001; POM3: 1.2 vs 3.6 ng/mL, <i>P</i> < 0.001). The postoperative decrease in AMH levels was higher in the EC group than the non-EC group on POD10 (0.8 vs 0.5 ng/mL, <i>P</i> = 0.011) but not on POM3 (0.7 vs 0.5 ng/mL, <i>P</i> = 0.164). Vasopressin injection during EC enucleation had no significant effect on the decrease in AMH levels on POD10 (vasopressin group vs non-vasopressin group: 1.0 vs 0.8 ng/mL, <i>P</i> = 0.253) and POM3 (vasopressin group vs nonvasopressin group: 1.4 vs 1.1 ng/mL, <i>P</i> = 0.242).</p><p><strong>Conclusions: </strong>AMH levels were lower at baseline and had higher decreasing rates after SPL surgery in the EC group relative to the non-EC group. Vasopressin injection might not protect the ovary from the postoperative decrease in AMH levels.</p>\",\"PeriodicalId\":16410,\"journal\":{\"name\":\"Journal of Menopausal Medicine\",\"volume\":\"27 3\",\"pages\":\"168-174\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/5e/jmm-27-168.PMC8738850.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Menopausal Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.6118/jmm.21031\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Menopausal Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6118/jmm.21031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
目的:比较子宫内膜异位症(ECs)和非子宫内膜异位症(ECs)患者血清抗苗勒管激素(AMH)水平，并分析单孔腹腔镜(SPL)卵巢囊肿去核术后抗苗勒管激素(AMH)水平变化。方法:共180例患者(EC组，n = 112;非ec组(n = 68)行SPL卵巢囊肿去核术进行回顾性分析。术前、术后第10天(POD10)和术后第3个月(POM3)分别检测AMH水平。根据肿瘤类型和抗利尿激素的使用分析AMH水平的变化。结果:EC组初始和术后血清AMH中位数水平均显著低于非EC组(术前:2.0 vs 3.8 ng/mL, P < 0.001;POD10: 1.0 vs 3.2 ng/mL, P < 0.001;POM3: 1.2 vs 3.6 ng/mL, P < 0.001)。在POD10上，EC组AMH水平的术后下降高于非EC组(0.8 vs 0.5 ng/mL, P = 0.011)，而在POM3上则没有(0.7 vs 0.5 ng/mL, P = 0.164)。在EC去核过程中注射抗利尿激素对POD10(抗利尿激素组vs非抗利尿激素组:1.0 vs 0.8 ng/mL, P = 0.253)和POM3(抗利尿激素组vs非抗利尿激素组:1.4 vs 1.1 ng/mL, P = 0.242) AMH水平的降低无显著影响。结论:与非EC组相比，EC组在SPL手术后AMH水平在基线时较低，且下降率较高。抗利尿激素注射可能不能保护卵巢免受术后AMH水平下降的影响。
Comparison of Serum Anti-Mullerian Hormone-Level Changes in Single-Port Laparoscopic Endometriotic and Non-Endometriotic Ovarian Cyst Enucleations.
Objectives: This study compared serum anti-Mullerian hormone (AMH) levels in endometriotic cysts (ECs) with those in non-ECs and analyzed changes thereof after single-port laparoscopic (SPL) ovarian cyst enucleation using vasopressin injection.
Methods: In total, 180 patients (EC group, n = 112; non-EC group, n = 68) who underwent SPL ovarian cyst enucleation were retrospectively reviewed. Their AMH levels were checked preoperatively, on postoperative day 10 (POD10), and on postoperative month 3 (POM3). Changes in AMH levels were analyzed according to tumor type and vasopressin use.
Results: The median initial and postoperative serum AMH levels in the EC group were significantly lower than those in the non-EC group (preoperation: 2.0 vs 3.8 ng/mL, P < 0.001; POD10: 1.0 vs 3.2 ng/mL, P < 0.001; POM3: 1.2 vs 3.6 ng/mL, P < 0.001). The postoperative decrease in AMH levels was higher in the EC group than the non-EC group on POD10 (0.8 vs 0.5 ng/mL, P = 0.011) but not on POM3 (0.7 vs 0.5 ng/mL, P = 0.164). Vasopressin injection during EC enucleation had no significant effect on the decrease in AMH levels on POD10 (vasopressin group vs non-vasopressin group: 1.0 vs 0.8 ng/mL, P = 0.253) and POM3 (vasopressin group vs nonvasopressin group: 1.4 vs 1.1 ng/mL, P = 0.242).
Conclusions: AMH levels were lower at baseline and had higher decreasing rates after SPL surgery in the EC group relative to the non-EC group. Vasopressin injection might not protect the ovary from the postoperative decrease in AMH levels.
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