子宫内膜癌上皮间质转移的特点。

Q3 Medicine

Experimental oncology Pub Date : 2021-12-01 DOI:10.32471/exp-oncology.2312-8852.vol-43-no-4.16982

I Nesina

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引用次数: 0

摘要

上皮-间质转化是肿瘤进展的重要组成部分，恶性肿瘤细胞因此具有侵袭性和迁移性。文献分析和我们自己的数据表明，参与上皮-间质转化的蛋白的激活对子宫内膜子宫内膜样癌的进展有重要影响，其表达的显著变异性可以决定这种癌症的临床和形态学异质性。最具侵袭性的子宫内膜样癌以上皮-间质混合表型为特征，通常与子宫内膜肿瘤细胞集体侵入肌层有关。

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Peculiarities of epithelial-mesenchimal transition in endometrial carcinomas.

Epithelial-mesenchymal transition is an important component of tumor progression, due to which the cells of malignant neoplasms acquire invasive and migratory properties. Analysis of the literature and our own data show that the activation of proteins involved in epithelial-mesenchymal transition crucially affects the progression of endometrioid carcinoma of the endometrium and the significant variability of their expression could determine the clinical and morphological heterogeneity of this cancer. The most aggressive endometrioid carcinomas of the endometrium are characterized by a hybrid epithelial-mesenchymal phenotype, which is often associated with a collective type of invasion of endometrial tumor cells into the myometrium.

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来源期刊

Experimental oncology Medicine-Oncology

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.