{"title":"约翰内斯堡一家三级医院妊娠期尿路感染的流行趋势：当代治疗建议是否恰当？","authors":"Trusha Nana, Shastra Bhoora, Vindana Chibabhai","doi":"10.4102/sajid.v36i1.328","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Urinary tract infections (UTIs) are common during pregnancy and are associated with maternal and foetal complications. Empiric antibiotic choices in pregnancy require consideration of efficacy and safety, resulting in limited oral options. With rapidly evolving antibiotic resistance, surveillance to guide empiric treatment recommendations is essential.</p><p><strong>Methods: </strong>A retrospective analysis of urine culture isolates from the Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) Obstetrics Department for 1 January 2015 to 31 December 2020 was performed.</p><p><strong>Results: </strong>The top 3 pathogens were <i>Escherichia coli, Enterococcus faecalis</i> and <i>Klebsiella pneumoniae</i>. For <i>E. coli</i> susceptibility to cefuroxime declined (95% to 81%, <i>p</i> < 0.0001). Similarly, the <i>E. coli</i> extended spectrum beta-lactamase rate increased from 5% to 10% (<i>p</i> = 0.04). <i>E. coli</i> susceptibility to nitrofurantoin (93%) and fosfomycin (96%) remained high. In 2019, carbapenem-resistant <i>K. pneumoniae</i> emerged. Ampicillin susceptibility was high amongst the <i>E. faecalis</i> isolates. Amoxicillin-clavulanate demonstrated high levels of activity against the top 3 uropathogens.</p><p><strong>Conclusion: </strong>The Essential Drug List recommended antibiotics for lower UTIs, nitrofurantoin and fosfomycin, are appropriate empiric options for <i>E. coli</i>, the most common uropathogen in the CMJAH obstetric population. The high rate of <i>E. faecalis</i> susceptibility to nitrofurantoin reported from other Gauteng tertiary obstetric patients, suggests that nitrofurantoin will provide adequate empiric cover for a large proportion of UTIs. However, the determination of the <i>E. faecalis</i> nitrofurantoin and fosfomycin susceptibility rates in the CMJAH obstetric population will provide useful data. Periodic surveillance at the various levels of antenatal care in different regions of South Africa and the determination of risk factors for infections with resistant uropathogens is needed.</p>","PeriodicalId":44007,"journal":{"name":"Southern African Journal of Infectious Diseases","volume":"36 1","pages":"328"},"PeriodicalIF":1.4000,"publicationDate":"2021-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678934/pdf/","citationCount":"0","resultStr":"{\"title\":\"Trends in the epidemiology of urinary tract infections in pregnancy at a tertiary hospital in Johannesburg: Are contemporary treatment recommendations appropriate?\",\"authors\":\"Trusha Nana, Shastra Bhoora, Vindana Chibabhai\",\"doi\":\"10.4102/sajid.v36i1.328\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Urinary tract infections (UTIs) are common during pregnancy and are associated with maternal and foetal complications. Empiric antibiotic choices in pregnancy require consideration of efficacy and safety, resulting in limited oral options. With rapidly evolving antibiotic resistance, surveillance to guide empiric treatment recommendations is essential.</p><p><strong>Methods: </strong>A retrospective analysis of urine culture isolates from the Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) Obstetrics Department for 1 January 2015 to 31 December 2020 was performed.</p><p><strong>Results: </strong>The top 3 pathogens were <i>Escherichia coli, Enterococcus faecalis</i> and <i>Klebsiella pneumoniae</i>. For <i>E. coli</i> susceptibility to cefuroxime declined (95% to 81%, <i>p</i> < 0.0001). Similarly, the <i>E. coli</i> extended spectrum beta-lactamase rate increased from 5% to 10% (<i>p</i> = 0.04). <i>E. coli</i> susceptibility to nitrofurantoin (93%) and fosfomycin (96%) remained high. In 2019, carbapenem-resistant <i>K. pneumoniae</i> emerged. Ampicillin susceptibility was high amongst the <i>E. faecalis</i> isolates. Amoxicillin-clavulanate demonstrated high levels of activity against the top 3 uropathogens.</p><p><strong>Conclusion: </strong>The Essential Drug List recommended antibiotics for lower UTIs, nitrofurantoin and fosfomycin, are appropriate empiric options for <i>E. coli</i>, the most common uropathogen in the CMJAH obstetric population. The high rate of <i>E. faecalis</i> susceptibility to nitrofurantoin reported from other Gauteng tertiary obstetric patients, suggests that nitrofurantoin will provide adequate empiric cover for a large proportion of UTIs. However, the determination of the <i>E. faecalis</i> nitrofurantoin and fosfomycin susceptibility rates in the CMJAH obstetric population will provide useful data. Periodic surveillance at the various levels of antenatal care in different regions of South Africa and the determination of risk factors for infections with resistant uropathogens is needed.</p>\",\"PeriodicalId\":44007,\"journal\":{\"name\":\"Southern African Journal of Infectious Diseases\",\"volume\":\"36 1\",\"pages\":\"328\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2021-12-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678934/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Southern African Journal of Infectious Diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4102/sajid.v36i1.328\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Southern African Journal of Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4102/sajid.v36i1.328","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Trends in the epidemiology of urinary tract infections in pregnancy at a tertiary hospital in Johannesburg: Are contemporary treatment recommendations appropriate?
Background: Urinary tract infections (UTIs) are common during pregnancy and are associated with maternal and foetal complications. Empiric antibiotic choices in pregnancy require consideration of efficacy and safety, resulting in limited oral options. With rapidly evolving antibiotic resistance, surveillance to guide empiric treatment recommendations is essential.
Methods: A retrospective analysis of urine culture isolates from the Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) Obstetrics Department for 1 January 2015 to 31 December 2020 was performed.
Results: The top 3 pathogens were Escherichia coli, Enterococcus faecalis and Klebsiella pneumoniae. For E. coli susceptibility to cefuroxime declined (95% to 81%, p < 0.0001). Similarly, the E. coli extended spectrum beta-lactamase rate increased from 5% to 10% (p = 0.04). E. coli susceptibility to nitrofurantoin (93%) and fosfomycin (96%) remained high. In 2019, carbapenem-resistant K. pneumoniae emerged. Ampicillin susceptibility was high amongst the E. faecalis isolates. Amoxicillin-clavulanate demonstrated high levels of activity against the top 3 uropathogens.
Conclusion: The Essential Drug List recommended antibiotics for lower UTIs, nitrofurantoin and fosfomycin, are appropriate empiric options for E. coli, the most common uropathogen in the CMJAH obstetric population. The high rate of E. faecalis susceptibility to nitrofurantoin reported from other Gauteng tertiary obstetric patients, suggests that nitrofurantoin will provide adequate empiric cover for a large proportion of UTIs. However, the determination of the E. faecalis nitrofurantoin and fosfomycin susceptibility rates in the CMJAH obstetric population will provide useful data. Periodic surveillance at the various levels of antenatal care in different regions of South Africa and the determination of risk factors for infections with resistant uropathogens is needed.
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