在肯尼亚进行的一项为期3年的试验中，氯菊酯和胡椒酰丁醇处理的杀虫蚊帐Olyset®Plus的生物功效和耐久性。

IF 4.8 1区医学 Q1 INFECTIOUS DISEASES

Infectious Diseases of Poverty Pub Date : 2021-12-20 DOI:10.1186/s40249-021-00916-2

Paul M Gichuki, Luna Kamau, Kiambo Njagi, Solomon Karoki, Njoroge Muigai, Damaris Matoke-Muhia, Nabie Bayoh, Evan Mathenge, Rajpal S Yadav

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引用次数: 8

摘要

背景:长效杀虫剂蚊帐(LLINs)是一项核心的疟疾干预措施。杀虫剂对蚊虫媒介的效力应至少保持三年。对氯菊酯和胡椒酰丁醇(PBO)处理的LLIN与氯菊酯处理的Olyset®Net的有效性和持久性进行了评估。由于缺乏世卫组织关于如何评估PBO蚊帐的指导方针，并考虑到制造商的产品声明，Olyset®Plus被评估为拟除虫菊酯LLIN。方法:2014 - 2017年在肯尼亚Kirinyaga县疟疾流行水稻种植区进行家庭随机对照试验。对基苏木冈比亚按蚊进行了锥生物测定和隧道试验。监测化学成分、织物完整性和LLIN存活率。使用卡方检验检验网间比较的显著性。百分比采用精确二项分布，95%置信区间(95% CI)。使用的WHO疗效标准是锥体生物测定中敲除率≥95%和/或死亡率≥80%，隧道试验中死亡率≥80%和/或血供抑制率≥90%。结果:在36个月时，Olyset®Plus减少了52%的氯菊酯和87%的PBO含量;Olyset®Net减少了24%的氯菊酯。超过80%的Olyset®Plus和Olyset®Net分别通过了WHO针对LLINs长达18个月和12个月的疗效标准。在第36个月，91.2%的Olyset®Plus和86.4%的Olyset®Net成活率，72%和63%的Olyset®Net至少钻了一个井眼。Olyset®Plus的比例孔指数(pHI)值分别为49.6%、27.1%和23.2%，Olyset®Net的比例孔指数(pHI)值分别为44.9%、32.8%和22.2%。结论:Olyset®Plus比Olyset®Net(1-1.5年)保持高于或接近WHO疗效标准约2年。这两种蚊帐都没有达到WHO的3年疗效标准，磨损很小，具有相当的物理耐久性和生存率，50%的Olyset®Plus在3年后具有良好和可使用的状态。更好地开展关于适当使用和维护LLIN的社区教育，对于确保基于LLIN的疟疾干预措施的有效性至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Bioefficacy and durability of Olyset® Plus, a permethrin and piperonyl butoxide-treated insecticidal net in a 3-year long trial in Kenya.

查看原文本刊更多论文

Bioefficacy and durability of Olyset^® Plus, a permethrin and piperonyl butoxide-treated insecticidal net in a 3-year long trial in Kenya.

Background: Long-lasting insecticide nets (LLINs) are a core malaria intervention. LLINs should retain efficacy against mosquito vectors for a minimum of three years. Efficacy and durability of Olyset^® Plus, a permethrin and piperonyl butoxide (PBO) treated LLIN, was evaluated versus permethrin treated Olyset^® Net. In the absence of WHO guidelines of how to evaluate PBO nets, and considering the manufacturer's product claim, Olyset^® Plus was evaluated as a pyrethroid LLIN.

Methods: This was a household randomized controlled trial in a malaria endemic rice cultivation zone of Kirinyaga County, Kenya between 2014 and 2017. Cone bioassays and tunnel tests were done against Anopheles gambiae Kisumu. The chemical content, fabric integrity and LLIN survivorship were monitored. Comparisons between nets were tested for significance using the Chi-square test. Exact binomial distribution with 95% confidence intervals (95% CI) was used for percentages. The WHO efficacy criteria used were ≥ 95% knockdown and/or ≥ 80% mortality rate in cone bioassays and ≥ 80% mortality and/or ≥ 90% blood-feeding inhibition in tunnel tests.

Results: At 36 months, Olyset^® Plus lost 52% permethrin and 87% PBO content; Olyset^® Net lost 24% permethrin. Over 80% of Olyset^® Plus and Olyset^® Net passed the WHO efficacy criteria for LLINs up to 18 and 12 months, respectively. At month 36, 91.2% Olyset^® Plus and 86.4% Olyset^® Net survived, while 72% and 63% developed at least one hole. The proportionate Hole Index (pHI) values representing nets in good, serviceable and torn condition were 49.6%, 27.1% and 23.2%, respectively for Olyset^® Plus, and 44.9%, 32.8% and 22.2%, respectively for Olyset^® Net but were not significantly different.

Conclusions: Olyset^® Plus retained efficacy above or close to the WHO efficacy criteria for about 2 years than Olyset^® Net (1-1.5 years). Both nets did not meet the 3-year WHO efficacy criteria, and showed little attrition, comparable physical durability and survivorship, with 50% of Olyset^® Plus having good and serviceable condition after 3 years. Better community education on appropriate use and upkeep of LLINs is essential to ensure effectiveness of LLIN based malaria interventions.

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来源期刊

Infectious Diseases of Poverty Medicine-Public Health, Environmental and Occupational Health

CiteScore

16.70

自引率

1.20%

发文量

368

审稿时长

13 weeks

期刊介绍： Infectious Diseases of Poverty is a peer-reviewed, open access journal that focuses on essential public health questions related to infectious diseases of poverty. It covers a wide range of topics and methods, including the biology of pathogens and vectors, diagnosis and detection, treatment and case management, epidemiology and modeling, zoonotic hosts and animal reservoirs, control strategies and implementation, new technologies, and their application. The journal also explores the impact of transdisciplinary or multisectoral approaches on health systems, ecohealth, environmental management, and innovative technologies. It aims to provide a platform for the exchange of research and ideas that can contribute to the improvement of public health in resource-limited settings. In summary, Infectious Diseases of Poverty aims to address the urgent challenges posed by infectious diseases in impoverished populations. By publishing high-quality research in various areas, the journal seeks to advance our understanding of these diseases and contribute to the development of effective strategies for prevention, diagnosis, and treatment.