2021年11月1日至26日，丹麦，用社区(BNT162b2 mRNA)疫苗诱导血清中和突变为E484K的SARS-CoV-2 δ变异亚系AY.4.2和B.1.617.2。

IF 7.8

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin Pub Date : 2021-12-01 DOI:10.2807/1560-7917.ES.2021.26.49.2101059

Ria Lassaunière, Charlotta Polacek, Jannik Fonager, Marc Bennedbæk, Lasse Boding, Morten Rasmussen, Anders Fomsgaard

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引用次数: 10

摘要

几个因素可能解释了最近SARS-CoV-2三角洲亚型谱系AY.4.2在英国、罗马尼亚、波兰和丹麦的传播增加。我们评估了2021年11月丹麦30名Comirnaty (BNT162b2 mRNA)疫苗接种者血清中和ay4.2的敏感性。AY.4.2中和作用与其他循环三角洲谱系或亚谱系相当。相反，含有E484K的不太流行的B.1.617.2的中和作用显著降低了4倍以上，这证明了对获得性E484K突变的菌株进行监测是有必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Neutralisation of the SARS-CoV-2 Delta variant sub-lineages AY.4.2 and B.1.617.2 with the mutation E484K by Comirnaty (BNT162b2 mRNA) vaccine-elicited sera, Denmark, 1 to 26 November 2021.

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Neutralisation of the SARS-CoV-2 Delta variant sub-lineages AY.4.2 and B.1.617.2 with the mutation E484K by Comirnaty (BNT162b2 mRNA) vaccine-elicited sera, Denmark, 1 to 26 November 2021.

Several factors may account for the recent increased spread of the SARS-CoV-2 Delta sub-lineage AY.4.2 in the United Kingdom, Romania, Poland, and Denmark. We evaluated the sensitivity of AY.4.2 to neutralisation by sera from 30 Comirnaty (BNT162b2 mRNA) vaccine recipients in Denmark in November 2021. AY.4.2 neutralisation was comparable to other circulating Delta lineages or sub-lineages. Conversely, the less prevalent B.1.617.2 with E484K showed a significant more than 4-fold reduction in neutralisation that warrants surveillance of strains with the acquired E484K mutation.

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Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

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