伴有同步或异时转移性疾病的2级组前列腺切除术标本中不良病理特征的患病率

The Prostate Pub Date : 2022-02-01 Epub Date: 2021-12-08 DOI:10.1002/pros.24279
Christopher Ma, Michelle Downes, Rahi Jain, Marc Ientilucci, Neil Fleshner, Nathan Perlis, Theodorus van der Kwast
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引用次数: 3

摘要

背景:为了验证最近建立的不良组织病理学特征(筛状模式和导管内癌)作为延缓治疗Gleason评分7(3 + 4)(分级组[GG] 2)前列腺癌的禁忌症的重要性,我们调查了它们在伴有同步或异时转移性疾病的GG2根治性前列腺切除术中的发生率。方法:在一家三级医疗中心的临床数据库中,对伴有淋巴结转移或远处转移的患者的GG2前列腺切除术标本进行随访,并对其病理分期、淋巴血管侵犯、Gleason 4级亚型、三级5级的存在和导管腺癌组织学进行回顾。对照组99例GG2前列腺切除术标本,无转移性疾病(对照组),检查相同的不良病理特征。结果:1860例GG2前列腺切除术标本(2002 - 2020年)中,45例(2.4%)随访时并发局部淋巴结转移或远处转移。病例和对照组的病理分期分布分别为pT2的24%和79%,pT3a的42%和15%,pT3b -T4的33%和6.1% (p)结论:明确的不良组织病理特征(导管内和筛状型癌,导管腺癌)在约90%的GG2前列腺癌中具有局部或远处转移性疾病,而在无转移性疾病的患者中较少见(38%)。引人注目的是,约25%伴有转移性疾病的GG2前列腺切除术病例有器官局限性疾病和/或一小部分Gleason 4级模式。这进一步强调了这些不良组织病理学特征(筛状、导管内和导管腺癌)作为GG2前列腺癌患者延迟治疗的对照指标的相对重要性,而不是Gleason分级4的百分比。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of adverse pathology features in grade group 2 prostatectomy specimens with syn- or metachronous metastatic disease.
To validate the importance of recently established adverse histopathology features (cribriform pattern and intraductal carcinoma) as contra‐indication for deferred treatment of Gleason score 7 (3 + 4) (grade group [GG] 2) prostate cancer, we investigated their frequency in GG2 radical prostatectomies with syn‐ or metachronous metastatic disease.
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